Human RhoGAP domain-containing proteins: structure, function and evolutionary relationships - PubMed (original) (raw)

Review

. 2002 Sep 25;528(1-3):27-34.

doi: 10.1016/s0014-5793(02)03331-8.

Affiliations

• PMID: 12297274
• DOI: 10.1016/s0014-5793(02)03331-8

Free article

Review

Human RhoGAP domain-containing proteins: structure, function and evolutionary relationships

Jeremy Peck et al. FEBS Lett. 2002.

Free article

Abstract

Proteins containing a RhoGAP (Rho GTPase activating protein) domain usually function to catalyze the hydrolysis of GTP that is bound to Rho, Rac and/or Cdc42, inactivating these regulators of the actin cytoskeleton. Using database searches, at least 53 distinct RhoGAP domain-containing proteins are likely to be encoded in human DNA. Phylogenetic analysis of only the RhoGAP domains divides these proteins into distinct families that appear to be functionally related. We also review the current understanding of the structure and likely functions of these human proteins. The presence of RhoGAP domains in a number of different human proteins suggests that cytoskeletal changes, regulated by Rho GTPase, may be integrated with many different signaling pathways.

PubMed Disclaimer

Similar articles

• Phylogenetic analysis of RhoGAP domain-containing proteins.
  Brandão MM, Silva-Brandão KL, Costa FF, Saad ST. Brandão MM, et al. Genomics Proteomics Bioinformatics. 2006 Aug;4(3):182-8. doi: 10.1016/S1672-0229(06)60031-4. Genomics Proteomics Bioinformatics. 2006. PMID: 17127216 Free PMC article.
• Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins.
  Nagaraja GM, Kandpal RP. Nagaraja GM, et al. Biochem Biophys Res Commun. 2004 Jan 16;313(3):654-65. doi: 10.1016/j.bbrc.2003.12.001. Biochem Biophys Res Commun. 2004. PMID: 14697242
• Deciphering the Molecular and Functional Basis of RHOGAP Family Proteins: A SYSTEMATIC APPROACH TOWARD SELECTIVE INACTIVATION OF RHO FAMILY PROTEINS.
  Amin E, Jaiswal M, Derewenda U, Reis K, Nouri K, Koessmeier KT, Aspenström P, Somlyo AV, Dvorsky R, Ahmadian MR. Amin E, et al. J Biol Chem. 2016 Sep 23;291(39):20353-71. doi: 10.1074/jbc.M116.736967. Epub 2016 Aug 1. J Biol Chem. 2016. PMID: 27481945 Free PMC article.
• Current knowledge of the large RhoGAP family of proteins.
  Tcherkezian J, Lamarche-Vane N. Tcherkezian J, et al. Biol Cell. 2007 Feb;99(2):67-86. doi: 10.1042/BC20060086. Biol Cell. 2007. PMID: 17222083 Review.
• Rho GTPase-activating proteins in cell regulation.
  Moon SY, Zheng Y. Moon SY, et al. Trends Cell Biol. 2003 Jan;13(1):13-22. doi: 10.1016/s0962-8924(02)00004-1. Trends Cell Biol. 2003. PMID: 12480336 Review.

Cited by

• The role of kinesin superfamily proteins in hepatocellular carcinoma.
  Ghnim ZS, Mahdi MS, Ballal S, Chahar M, Verma R, Al-Nuaimi AMA, Kumar MR, Al-Hussein RKA, Adil M, Jawad MJ. Ghnim ZS, et al. Med Oncol. 2024 Oct 14;41(11):271. doi: 10.1007/s12032-024-02497-0. Med Oncol. 2024. PMID: 39400594 Review.
• XTP8 Promotes Ovarian Cancer Progression by Activating AKT/AMPK/mTOR Pathway to Regulate EMT.
  Zhao R, Ning X, Lu H, Xu W, Ma J, Cheng J, Ma R. Zhao R, et al. Cell Biochem Biophys. 2024 Jun;82(2):945-957. doi: 10.1007/s12013-024-01246-4. Epub 2024 Mar 13. Cell Biochem Biophys. 2024. PMID: 38717641 Free PMC article.
• Oligodontia in the Clinical Spectrum of Syndromes: A Systematic Review.
  Castilho NL, Resende KKM, Santos JAD, Machado RA, Coletta RD, Guerra ENS, Acevedo AC, Martelli-Junior H. Castilho NL, et al. Dent J (Basel). 2023 Dec 4;11(12):279. doi: 10.3390/dj11120279. Dent J (Basel). 2023. PMID: 38132417 Free PMC article. Review.
• Diverse targets of SMN2-directed splicing-modulating small molecule therapeutics for spinal muscular atrophy.
  Ottesen EW, Singh NN, Luo D, Kaas B, Gillette BJ, Seo J, Jorgensen HJ, Singh RN. Ottesen EW, et al. Nucleic Acids Res. 2023 Jul 7;51(12):5948-5980. doi: 10.1093/nar/gkad259. Nucleic Acids Res. 2023. PMID: 37026480 Free PMC article.
• Loss of ARHGAP15 affects the directional control of migrating interneurons in the embryonic cortex and increases susceptibility to epilepsy.
  Liaci C, Camera M, Zamboni V, Sarò G, Ammoni A, Parmigiani E, Ponzoni L, Hidisoglu E, Chiantia G, Marcantoni A, Giustetto M, Tomagra G, Carabelli V, Torelli F, Sala M, Yanagawa Y, Obata K, Hirsch E, Merlo GR. Liaci C, et al. Front Cell Dev Biol. 2022 Dec 8;10:875468. doi: 10.3389/fcell.2022.875468. eCollection 2022. Front Cell Dev Biol. 2022. PMID: 36568982 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science
  • Wiley

• Other Literature Sources

  • The Lens - Patent Citations

• Molecular Biology Databases

  • BioCyc

• Miscellaneous

  • NCI CPTAC Assay Portal