Depletion of mesopontine cholinergic and sparing of raphe neurons in multiple system atrophy - PubMed (original) (raw)
Comparative Study
. 2002 Sep 24;59(6):944-6.
doi: 10.1212/wnl.59.6.944.
Affiliations
- PMID: 12297588
- DOI: 10.1212/wnl.59.6.944
Comparative Study
Depletion of mesopontine cholinergic and sparing of raphe neurons in multiple system atrophy
Eduardo E Benarroch et al. Neurology. 2002.
Abstract
The authors immunocytochemically identified mesopontine cholinergic and rostral raphe serotonergic neurons in brains obtained at autopsy from four patients with multiple system atrophy (MSA) and four matched controls. There was a severe depletion of cholinergic neurons in the pedunculopontine (20 +/- 2 vs 81 +/- 10 cells/section, p< 0.001) and laterodorsal tegmental nucleus (18 +/- 3 vs 47 +/- 4 cells/section, p < 0.001) in MSA. Whereas there was also depletion of locus ceruleus neurons, there was a striking preservation of rostral raphe neurons in MSA.
Similar articles
- Mesopontine cholinergic neuron involvement in Lewy body dementia and multiple system atrophy.
Schmeichel AM, Buchhalter LC, Low PA, Parisi JE, Boeve BW, Sandroni P, Benarroch EE. Schmeichel AM, et al. Neurology. 2008 Jan 29;70(5):368-73. doi: 10.1212/01.wnl.0000298691.71637.96. Neurology. 2008. PMID: 18227417 - Mesopontine cholinergic and non-cholinergic neurons in schizophrenia.
German DC, Manaye KF, Wu D, Hersh LB, Zweig RM. German DC, et al. Neuroscience. 1999;94(1):33-8. doi: 10.1016/s0306-4522(99)00305-x. Neuroscience. 1999. PMID: 10613494 - Rostral raphe involvement in Lewy body dementia and multiple system atrophy.
Benarroch EE, Schmeichel AM, Sandroni P, Parisi JE, Low PA. Benarroch EE, et al. Acta Neuropathol. 2007 Sep;114(3):213-20. doi: 10.1007/s00401-007-0260-3. Epub 2007 Jul 17. Acta Neuropathol. 2007. PMID: 17639427 - Depletion of corticotrophin-releasing factor neurons in the pontine micturition area in multiple system atrophy.
Benarroch EE, Schmeichel AM. Benarroch EE, et al. Ann Neurol. 2001 Nov;50(5):640-5. doi: 10.1002/ana.1258. Ann Neurol. 2001. PMID: 11706970 - Brainstem in multiple system atrophy: clinicopathological correlations.
Benarroch EE. Benarroch EE. Cell Mol Neurobiol. 2003 Oct;23(4-5):519-26. doi: 10.1023/a:1025067912199. Cell Mol Neurobiol. 2003. PMID: 14514012 Review.
Cited by
- Multiple system atrophy - a clinicopathological update.
Jellinger KA. Jellinger KA. Free Neuropathol. 2020 Jul 3;1:1-17. doi: 10.17879/freeneuropathology-2020-2813. eCollection 2020 Jan. Free Neuropathol. 2020. PMID: 37283673 Free PMC article. - Depression in multiple system atrophy: Views on pathological, clinical and imaging aspects.
Lv Q, Pan Y, Chen X, Wei J, Wang W, Zhang H, Wan J, Li S, Zhuang Y, Yang B, Ma D, Ren D, Zhao Z. Lv Q, et al. Front Psychiatry. 2022 Sep 8;13:980371. doi: 10.3389/fpsyt.2022.980371. eCollection 2022. Front Psychiatry. 2022. PMID: 36159911 Free PMC article. Review. - Intraocular pressure and choroidal thickness postural changes in multiple system atrophy and Parkinson's disease.
De Bernardo M, Salerno G, Gioia M, Capasso L, Russillo MC, Picillo M, Erro R, Amboni M, Barone P, Rosa N, Pellecchia MT. De Bernardo M, et al. Sci Rep. 2021 Apr 26;11(1):8936. doi: 10.1038/s41598-021-88250-3. Sci Rep. 2021. PMID: 33903644 Free PMC article. Clinical Trial. - Differential abnormalities of cerebrospinal fluid dopaminergic versus noradrenergic indices in synucleinopathies.
Goldstein DS, Sullivan P, Holmes C, Lamotte G, Lenka A, Sharabi Y. Goldstein DS, et al. J Neurochem. 2021 Jul;158(2):554-568. doi: 10.1111/jnc.15371. Epub 2021 May 21. J Neurochem. 2021. PMID: 33894018 Free PMC article. - Mechanisms of Neurodegeneration in Various Forms of Parkinsonism-Similarities and Differences.
Koziorowski D, Figura M, Milanowski ŁM, Szlufik S, Alster P, Madetko N, Friedman A. Koziorowski D, et al. Cells. 2021 Mar 16;10(3):656. doi: 10.3390/cells10030656. Cells. 2021. PMID: 33809527 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources