Inhibition of TNFalpha-induced cyclooxygenase-2 expression by amentoflavone through suppression of NF-kappaB activation in A549 cells - PubMed (original) (raw)

Inhibition of TNFalpha-induced cyclooxygenase-2 expression by amentoflavone through suppression of NF-kappaB activation in A549 cells

Tinku Banerjee et al. Mol Cell Biochem. 2002 Sep.

Abstract

Amentoflavone, a biflavonoid with antiinflammatory activity, downregulates COX-2 expression in TNFalpha-activatedA549 cells with concomitant inhibition of NF-kappaB mediated signaling cascades. We demonstrate here that amentoflavone inhibits NF-kappaB/ DNA binding activity potently along with inhibition of degradation of IkappaBalpha and NF-kappaB translocation into nucleus in TNFalpha-activated A549 cells. This flavonoid upregulates PPAR gamma, a transcription factor involved in repressing many cytokine-induced gene expressions. Hence amentoflavone, a dietary constituent, may be of therapeutic value for several lung diseases where COX-2 plays an important role.

PubMed Disclaimer

Similar articles

• Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-kappa B activation.
  Surh YJ, Chun KS, Cha HH, Han SS, Keum YS, Park KK, Lee SS. Surh YJ, et al. Mutat Res. 2001 Sep 1;480-481:243-68. doi: 10.1016/s0027-5107(01)00183-x. Mutat Res. 2001. PMID: 11506818 Review.
• Flavonoids: Food associations, therapeutic mechanisms, metabolism and nanoformulations.
  Kaushal N, Singh M, Singh Sangwan R. Kaushal N, et al. Food Res Int. 2022 Jul;157:111442. doi: 10.1016/j.foodres.2022.111442. Epub 2022 May 30. Food Res Int. 2022. PMID: 35761682 Review.

Cited by

• Chemopreventive mechanisms of amentoflavone: recent trends and advancements.
  Tuli HS, Joshi H, Vashishth K, Ramniwas S, Varol M, Kumar M, Rani I, Rani V, Sak K. Tuli HS, et al. Naunyn Schmiedebergs Arch Pharmacol. 2023 May;396(5):865-876. doi: 10.1007/s00210-023-02416-6. Epub 2023 Feb 11. Naunyn Schmiedebergs Arch Pharmacol. 2023. PMID: 36773053 Review.
• Acute Toxicity and Anti-Inflammatory Activity of Trattinnickia rhoifolia Willd (Sucuruba) Using the Zebrafish Model.
  de Souza AA, Ortíz BLS, Borges SF, Pinto AVP, Ramos RDS, Pena IC, Rocha Koga RC, Batista CE, de Souza GC, Ferreira AM, Duvoisin Junior S, Tavares Carvalho JC. de Souza AA, et al. Molecules. 2022 Nov 10;27(22):7741. doi: 10.3390/molecules27227741. Molecules. 2022. PMID: 36431841 Free PMC article.
• Onosma L. as a source of anticancer agents: phytochemistry to mechanistic insight.
  Kumar A, Attri S, Kaur S, Tuli HS, Saini RV, Saini AK, Kumar M, Kaur S. Kumar A, et al. Explor Target Antitumor Ther. 2022;3(5):719-733. doi: 10.37349/etat.2022.00109. Epub 2022 Oct 31. Explor Target Antitumor Ther. 2022. PMID: 36338520 Free PMC article. Review.
• Insights Into Amentoflavone: A Natural Multifunctional Biflavonoid.
  Xiong X, Tang N, Lai X, Zhang J, Wen W, Li X, Li A, Wu Y, Liu Z. Xiong X, et al. Front Pharmacol. 2021 Dec 22;12:768708. doi: 10.3389/fphar.2021.768708. eCollection 2021. Front Pharmacol. 2021. PMID: 35002708 Free PMC article. Review.
• Proceedings of Chemistry, Pharmacology, Pharmacokinetics and Synthesis of Biflavonoids.
  He X, Yang F, Huang X. He X, et al. Molecules. 2021 Oct 8;26(19):6088. doi: 10.3390/molecules26196088. Molecules. 2021. PMID: 34641631 Free PMC article. Review.

References

1. 1. Arch Pharm Res. 1998 Aug;21(4):406-10 - PubMed
2. 1. J Cell Biol. 1995 Mar;128(6):1111-9 - PubMed
3. 1. J Nat Prod. 2000 May;63(5):627-30 - PubMed
4. 1. J Biol Chem. 1995 Jul 14;270(28):16483-6 - PubMed
5. 1. Carcinogenesis. 1999 Oct;20(10):1945-52 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Ovid Technologies, Inc.

• Research Materials

  • NCI CPTC Antibody Characterization Program