Does size matter? - PubMed (original) (raw)

Review

Does size matter?

William A Wells. J Cell Biol. 2002.

Abstract

For 40 years, the debate has raged. Do mammalian cells monitor cell size when deciding whether to divide? More recent models suggest an indirect solution, but the field is far from reaching a final verdict.

PubMed Disclaimer

Figures

Figure 1.

Figure 1.

Cells that start off G1 larger gain less mass during G1. Correlations such as this led Zetterberg to propose that size control applies in mammalian cells (see text). Zetterberg/Elsevier

References

    1. Brooks, R.F., and R. Shields. 1985. Cell growth, cell division and cell size homeostasis in Swiss 3T3 cells. Exp. Cell Res. 156:1–6. - PubMed
    1. Conlon, I.J., G.D. Dunn, A.W. Mudge, and M.C. Raff. 2001. Extracellular control of cell size. Nat. Cell Biol. 3:918–921. - PubMed
    1. Daga, R.R., and J. Jiminez. 1999. Translational control of the Cdc25 cell cycle phosphatase: a molecular mechanism coupling mitosis to cell growth. J. Cell Sci. 112:3137–3146. - PubMed
    1. Fantes, P., and P. Nurse. 1977. Control of cell size at division in fission yeast by a growth-modulated size control over nuclear division. Exp. Cell Res. 107:377–386. - PubMed
    1. Fox, T.O., and A.B. Pardee. 1970. Animal cells: noncorrelation of length of G1 phase with size after mitosis. Science. 167:80–82. - PubMed

Publication types

MeSH terms

LinkOut - more resources