Breast cancer banishes p27 from nucleus - PubMed (original) (raw)

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Breast cancer banishes p27 from nucleus

Stacy W Blain et al. Nat Med. 2002 Oct.

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• PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization.
  Shin I, Yakes FM, Rojo F, Shin NY, Bakin AV, Baselga J, Arteaga CL. Shin I, et al. Nat Med. 2002 Oct;8(10):1145-52. doi: 10.1038/nm759. Epub 2002 Sep 16. Nat Med. 2002. PMID: 12244301
• PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest.
  Liang J, Zubovitz J, Petrocelli T, Kotchetkov R, Connor MK, Han K, Lee JH, Ciarallo S, Catzavelos C, Beniston R, Franssen E, Slingerland JM. Liang J, et al. Nat Med. 2002 Oct;8(10):1153-60. doi: 10.1038/nm761. Epub 2002 Sep 16. Nat Med. 2002. PMID: 12244302
• Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer.
  Viglietto G, Motti ML, Bruni P, Melillo RM, D'Alessio A, Califano D, Vinci F, Chiappetta G, Tsichlis P, Bellacosa A, Fusco A, Santoro M. Viglietto G, et al. Nat Med. 2002 Oct;8(10):1136-44. doi: 10.1038/nm762. Epub 2002 Sep 16. Nat Med. 2002. PMID: 12244303

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