Unravelling the pathogenesis of myasthenia gravis - PubMed (original) (raw)
Review
. 2002 Oct;2(10):797-804.
doi: 10.1038/nri916.
Affiliations
- PMID: 12360217
- DOI: 10.1038/nri916
Review
Unravelling the pathogenesis of myasthenia gravis
Angela Vincent. Nat Rev Immunol. 2002 Oct.
Abstract
Myasthenia gravis is a relatively rare neurological disease that is associated with loss of the acetylcholine receptors that initiate muscle contraction. This results in muscle weakness, which can be life-threatening. The story of how both the physiological basis of the disease and the role of acetylcholine-receptor-specific antibodies were determined is a classic example of the application of basic science to clinical medicine, and it has provided a model for defining other antibody-mediated disorders of the peripheral and central nervous systems.
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