Regulation and function of local protein synthesis in neuronal dendrites - PubMed (original) (raw)
Review
Regulation and function of local protein synthesis in neuronal dendrites
Changan Jiang et al. Trends Biochem Sci. 2002 Oct.
Abstract
It has long been shown that protein synthesis can occur in neuronal dendrites, but its significance remained unclear until relatively recently. Studies suggest that local protein synthesis has crucial roles in synaptic plasticity, the change in neuronal communication efficiency that is probably a cellular basis of learning and memory. Induced by neuronal activity, local protein synthesis provides key factors for the modification of activated synapses. In this review, we summarize the evidence for local protein synthesis and its functions in synaptic plasticity. We also discuss the molecular mechanisms by which neuronal activity induces the synthesis of proteins that allow for changes in synaptic function.
Comment in
- The protein synthesis world.
Schimmel P. Schimmel P. Trends Biochem Sci. 2002 Oct;27(10):505-6. doi: 10.1016/s0968-0004(02)02203-x. Trends Biochem Sci. 2002. PMID: 12368085
Similar articles
- [Protein local synthesis in neuronal processes].
Lu L, Lu PH, Sheng ZH. Lu L, et al. Sheng Li Ke Xue Jin Zhan. 2004 Jul;35(3):259-61. Sheng Li Ke Xue Jin Zhan. 2004. PMID: 15469101 Review. Chinese. No abstract available. - Local synthesis of proteins at synaptic sites on dendrites: role in synaptic plasticity and memory consolidation?
Steward O, Worley P. Steward O, et al. Neurobiol Learn Mem. 2002 Nov;78(3):508-27. doi: 10.1006/nlme.2002.4102. Neurobiol Learn Mem. 2002. PMID: 12559831 - RNA trafficking and local protein synthesis in dendrites: an overview.
Martin KC, Zukin RS. Martin KC, et al. J Neurosci. 2006 Jul 5;26(27):7131-4. doi: 10.1523/JNEUROSCI.1801-06.2006. J Neurosci. 2006. PMID: 16822966 Free PMC article. Review. - Local protein synthesis during axon guidance and synaptic plasticity.
Martin KC. Martin KC. Curr Opin Neurobiol. 2004 Jun;14(3):305-10. doi: 10.1016/j.conb.2004.05.009. Curr Opin Neurobiol. 2004. PMID: 15194110 Review. - Synaptic plasticity: regulated translation in dendrites.
Huang EP. Huang EP. Curr Biol. 1999 Mar 11;9(5):R168-70. doi: 10.1016/s0960-9822(99)80104-3. Curr Biol. 1999. PMID: 10074442 Review.
Cited by
- APOE4 Affects Basal and NMDAR-Mediated Protein Synthesis in Neurons by Perturbing Calcium Homeostasis.
Ramakrishna S, Jhaveri V, Konings SC, Nawalpuri B, Chakraborty S, Holst B, Schmid B, Gouras GK, Freude KK, Muddashetty RS. Ramakrishna S, et al. J Neurosci. 2021 Oct 20;41(42):8686-8709. doi: 10.1523/JNEUROSCI.0435-21.2021. Epub 2021 Sep 2. J Neurosci. 2021. PMID: 34475200 Free PMC article. - Memory consolidation and improvement by synaptic tagging and capture in recurrent neural networks.
Luboeinski J, Tetzlaff C. Luboeinski J, et al. Commun Biol. 2021 Mar 3;4(1):275. doi: 10.1038/s42003-021-01778-y. Commun Biol. 2021. PMID: 33658641 Free PMC article. - Molecular Mechanisms of Reconsolidation-Dependent Memory Updating.
Bellfy L, Kwapis JL. Bellfy L, et al. Int J Mol Sci. 2020 Sep 9;21(18):6580. doi: 10.3390/ijms21186580. Int J Mol Sci. 2020. PMID: 32916796 Free PMC article. Review. - hCLE/RTRAF-HSPC117-DDX1-FAM98B: A New Cap-Binding Complex That Activates mRNA Translation.
Pazo A, Pérez-González A, Oliveros JC, Huarte M, Chavez JP, Nieto A. Pazo A, et al. Front Physiol. 2019 Feb 18;10:92. doi: 10.3389/fphys.2019.00092. eCollection 2019. Front Physiol. 2019. PMID: 30833903 Free PMC article. - Rapid, experience-dependent translation of neurogranin enables memory encoding.
Jones KJ, Templet S, Zemoura K, Kuzniewska B, Pena FX, Hwang H, Lei DJ, Haensgen H, Nguyen S, Saenz C, Lewis M, Dziembowska M, Xu W. Jones KJ, et al. Proc Natl Acad Sci U S A. 2018 Jun 19;115(25):E5805-E5814. doi: 10.1073/pnas.1716750115. Epub 2018 Jun 7. Proc Natl Acad Sci U S A. 2018. PMID: 29880715 Free PMC article.