Microglia as neuroprotective, immunocompetent cells of the CNS - PubMed (original) (raw)
Review
. 2002 Nov;40(2):133-139.
doi: 10.1002/glia.10154.
Affiliations
- PMID: 12379901
- DOI: 10.1002/glia.10154
Review
Microglia as neuroprotective, immunocompetent cells of the CNS
Wolfgang J Streit. Glia. 2002 Nov.
Abstract
The role of glial cells is to support and sustain proper neuronal function and microglia are no exception to this. This viewpoint article emphasizes the fundamental interdependence of microglia and neurons and takes a look at the possibility of what could happen if microglial cells became dysfunctional as a result of aging, genetics, or epigenetics. Could microglial senescence be a factor in the pathogenesis of Alzheimer's and other neurodegenerative diseases? The cautious answer to that question is 'yes'. Future studies along these lines may provide novel insights into microglial involvement in neurodegenerative disease pathogenesis.
Copyright 2002 Wiley-Liss, Inc.
Similar articles
- Microglia as a source and target of cytokines.
Hanisch UK. Hanisch UK. Glia. 2002 Nov;40(2):140-155. doi: 10.1002/glia.10161. Glia. 2002. PMID: 12379902 Review. - Control of glial immune function by neurons.
Neumann H. Neumann H. Glia. 2001 Nov;36(2):191-9. doi: 10.1002/glia.1108. Glia. 2001. PMID: 11596127 Review. - Generation and characterization of immortalized human microglial cell lines: expression of cytokines and chemokines.
Nagai A, Nakagawa E, Hatori K, Choi HB, McLarnon JG, Lee MA, Kim SU. Nagai A, et al. Neurobiol Dis. 2001 Dec;8(6):1057-68. doi: 10.1006/nbdi.2001.0437. Neurobiol Dis. 2001. PMID: 11741401 - Evidence for a novel chemotactic C1q domain-containing factor in the leech nerve cord.
Tahtouh M, Croq F, Vizioli J, Sautiere PE, Van Camp C, Salzet M, Daha MR, Pestel J, Lefebvre C. Tahtouh M, et al. Mol Immunol. 2009 Feb;46(4):523-31. doi: 10.1016/j.molimm.2008.07.026. Epub 2008 Oct 25. Mol Immunol. 2009. PMID: 18952286 - Chemokine receptors in the central nervous system: role in brain inflammation and neurodegenerative diseases.
Cartier L, Hartley O, Dubois-Dauphin M, Krause KH. Cartier L, et al. Brain Res Brain Res Rev. 2005 Feb;48(1):16-42. doi: 10.1016/j.brainresrev.2004.07.021. Brain Res Brain Res Rev. 2005. PMID: 15708626 Review.
Cited by
- Aging Microglia and Their Impact in the Nervous System.
von Bernhardi R, Eugenín J. von Bernhardi R, et al. Adv Neurobiol. 2024;37:379-395. doi: 10.1007/978-3-031-55529-9_21. Adv Neurobiol. 2024. PMID: 39207703 Review. - Alcohol, HMGB1, and Innate Immune Signaling in the Brain.
Crews FT, Coleman LG Jr, Macht VA, Vetreno RP. Crews FT, et al. Alcohol Res. 2024 Aug 8;44(1):04. doi: 10.35946/arcr.v44.1.04. eCollection 2024. Alcohol Res. 2024. PMID: 39135668 Free PMC article. Review. - Arylphthalide Delays Diabetic Retinopathy via Immunomodulating the Early Inflammatory Response in an Animal Model of Type 1 Diabetes Mellitus.
Martín-Loro F, Cano-Cano F, Ortega MJ, Cuevas B, Gómez-Jaramillo L, González-Montelongo MDC, Freisenhausen JC, Lara-Barea A, Campos-Caro A, Zubía E, Aguilar-Diosdado M, Arroba AI. Martín-Loro F, et al. Int J Mol Sci. 2024 Aug 2;25(15):8440. doi: 10.3390/ijms25158440. Int J Mol Sci. 2024. PMID: 39126007 Free PMC article. - Microglia Gravitate toward Amyloid Plaques Surrounded by Externalized Phosphatidylserine via TREM2.
Park JC, Han JW, Lee W, Kim J, Lee SE, Lee D, Choi H, Han J, Kang YJ, Diep YN, Cho H, Kang R, Yu WJ, Lee J, Choi M, Im SW, Kim JI, Mook-Jung I. Park JC, et al. Adv Sci (Weinh). 2024 Sep;11(34):e2400064. doi: 10.1002/advs.202400064. Epub 2024 Jul 9. Adv Sci (Weinh). 2024. PMID: 38981007 Free PMC article. - Role of Facial Nerve Reconstruction With Anastomosis and Polyglycolic Acid Tube in Accelerating Functional Recovery After Axotomy in the Rat Facial Nucleus.
Noda M, Koshu R, Takaso Y, Sajjaviriya C, Ito M, Koshimizu T. Noda M, et al. Cureus. 2024 Mar 31;16(3):e57326. doi: 10.7759/cureus.57326. eCollection 2024 Mar. Cureus. 2024. PMID: 38690467 Free PMC article.
References
REFERENCES
- Akiyama H, McGeer PL. 1990. Brain microglia constitutively express beta-2 integrins. J Neuroimmunol 30: 81-93.
- Akiyama H, Barger S, Barnum S, Bradt B, Bauer J, Cole GM, Cooper NR, Eikelenboom P, Emmerling M, Fiebich BL, Finch CE, Frautschy S, Griffin WST, Hampel H, Hull M, Landreth G, Lue LF, Mrak R, Mackenzie M, O'Banion K, Pachter J, Pasinetti G, Plata-Salaman C, Rogers J, Rydel R, Shen Y, Streit W, Strohmeyer R, Tooyoma I, Van Muiswinkel FL, Veerhuis R, Walker D, Webster S, Wegrzyniak B, Wenk G, Wyss-Coray A. 2000. Inflammation and Alzheimer's Disease. Neurobiol Aging 21: 383-421.
- Albright AV, Shieh JT, Itoh T, Lee B, Pleasure D, O'Connor MJ, Doms RW, Gonzalez-Scarano F. 1999. Microglia express CCR5, CXCR4, and CCR3, but of these, CCR5 is the principal coreceptor for human immunodeficiency virus type 1 dementia isolates. J Virol 73: 205-213.
- Barron KD, Marciano FF, Amundson R, Mankes R. 1990. Perineuronal glial responses after axotomy of central and peripheral axons. A comparison. Brain Res 523: 219-229.
- Bell MD, Lopez-Gonzalez R, Lawson L, Hughes D, Fraser I, Gordon S, Perry VH. 1994. Upregulation of the macrophage scavenger receptor in response to different forms of injury in the CNS. J Neurocytol 23: 605-613.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources