Microglia as liaisons between the immune and central nervous systems: functional implications for multiple sclerosis - PubMed (original) (raw)

Review

Microglia as liaisons between the immune and central nervous systems: functional implications for multiple sclerosis

Monica J Carson. Glia. 2002 Nov.

Abstract

Multiple sclerosis is a chronic demyelinating inflammatory disease of the central nervous system (CNS). As the tissue macrophage of the CNS, microglia have the potential to regulate and be regulated by cells of the CNS and by CNS-infiltrating immune cells. The exquisite sensitivity of microglia to these signals, coupled with their ability to develop a broad range of effector functions, allows the CNS to tailor microglial function for specific physiological needs. However, the great plasticity of microglial responses can also predispose these cells to amplify disproportionately the irrelevant or dysfunctional signals provided by either the CNS or immune systems. The consequences of such an event could be the conversion of self-limiting inflammatory responses into chronic neurodegeneration and may explain in part the heterogeneous nature of multiple sclerosis.

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Figures

Fig. 1

Knowing when to stop. Microglia are capable of developing a broad range of effector functions, determined in part by environmental signals from neurons, glia, and CNS-infiltrating immune cells and in part to their prior activation/developmental state. Their great plasticity and sensitivity to external cues allow for fine control of microglial effector function but also predispose microglia to develop maladaptive functions in response to dysregulated environmental signals. APC, antigen-presenting cell.

References

1. Aloisi F. Immune function of microglia. Glia. 2001;36:165–179. - PubMed
1. Aloisi F, Penna G, Polazzi E, Minghetti L, Adorini L. CD40-CD154 interaction and IFN-gamma are required for IL-12 but not prostaglandin E2 secretion by microglia during antigen presentation to Th1 cells. J Immunol. 1999;162:1384–1391. - PubMed
1. Aloisi F, Ria F, Adorini L. Regulation of T-cell responses by CNS antigen-presenting cells: different roles for microglia and astrocytes. Immunol Today. 2000a;21:141–147. - PubMed
1. Aloisi F, De Simone R, Columba-Cabezas S, Penna G, Adorini L. Functional maturation of adult mouse resting microglia into an APC is promoted by granulocyte-macrophage colony-stimulating factor and interaction with Th1 cells. J Immunol. 2000b;164:1705–1712. - PubMed
1. Aschner M, Allen JW, Kimelberg HK, LoPachin RM, Streit WJ. Glial cells in neurotoxicity development. Annu Rev Pharmacol Toxicol. 1999;39:151–173. - PubMed

Microglia as liaisons between the immune and central nervous systems: functional implications for multiple sclerosis - PubMed (original) (raw)