An electrophoretic study of the distribution and properties of human hexokinases - PubMed (original) (raw)

. 1975 Dec;13(11-12):857-66.

doi: 10.1007/BF00484416.

An electrophoretic study of the distribution and properties of human hexokinases

P A Rogers et al. Biochem Genet. 1975 Dec.

Abstract

An electrophoretic system which gives a clear separation of human hexokinases HK1, HK2 and HK3 is described. The distribution of the hexokinase isozymes in various human tissues, both adult and fetal, is reported. Some properties of the isozymes were investigated. HK2 was found to be more thermolabile than HK1, and there was also a small but significant difference in molecular size. Unlike HK3, HK1 and HK2 are not inhibited by high glucose concentrations. Screening of red cell lysates from 800 unrelated European individuals revealed no genetic variants of HK1 and HK2. However, in view of their difference in properties, it seems probable that the HK1 and HK2 isozymes are determined by separate gene loci.

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References

    1. J Biol Chem. 1966 Aug 10;241(15):3546-60 - PubMed
    1. Ann Hum Genet. 1969 Jul;33(1):89-92 - PubMed
    1. Biochem Biophys Res Commun. 1965 Apr 23;19:377-82 - PubMed
    1. Blood. 1970 Aug;36(2):219-27 - PubMed
    1. Ann Hum Genet. 1970 Jul;34(1):61-71 - PubMed

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