Transcriptional accessibility for genes of multiple tissues and hematopoietic lineages is hierarchically controlled during early hematopoiesis - PubMed (original) (raw)
. 2003 Jan 15;101(2):383-9.
doi: 10.1182/blood-2002-06-1780. Epub 2002 Sep 5.
Affiliations
- PMID: 12393558
- DOI: 10.1182/blood-2002-06-1780
Free article
Transcriptional accessibility for genes of multiple tissues and hematopoietic lineages is hierarchically controlled during early hematopoiesis
Koichi Akashi et al. Blood. 2003.
Free article
Abstract
Hematopoietic stem cells (HSCs) maintain hematopoiesis by giving rise to all types of blood cells. Recent reports suggest that HSCs also possess the potential to generate nonhematopoietic tissues. To evaluate the underlying mechanisms in the commitment of HSCs into multitissue and multihematopoietic lineages, we performed oligonucleotide array analyses targeting for prospectively purified HSCs, multipotent progenitors (MPPs), common lymphoid progenitors (CLPs), and common myeloid progenitors (CMPs). Here we show that HSCs coexpress multiple nonhematopoietic genes as well as hematopoietic genes; MPPs coexpress myeloid and lymphoid genes; CMPs coexpress myeloerythroid, but not lymphoid genes, whereas CLPs coexpress T-, B-, and natural killer-lymphoid, but not myeloid, genes. Thus, the stepwise decrease in transcriptional accessibility for multilineage-affiliated genes may represent progressive restriction of developmental potentials in early hematopoiesis. These data support the hypothesis that stem cells possess a wide-open chromatin structure to maintain their multipotentiality, which is progressively quenched as they go down a particular pathway of differentiation.
Similar articles
- Myeloid or lymphoid promiscuity as a critical step in hematopoietic lineage commitment.
Miyamoto T, Iwasaki H, Reizis B, Ye M, Graf T, Weissman IL, Akashi K. Miyamoto T, et al. Dev Cell. 2002 Jul;3(1):137-47. doi: 10.1016/s1534-5807(02)00201-0. Dev Cell. 2002. PMID: 12110174 - Gene expression analysis of purified hematopoietic stem cells and committed progenitors.
Terskikh AV, Miyamoto T, Chang C, Diatchenko L, Weissman IL. Terskikh AV, et al. Blood. 2003 Jul 1;102(1):94-101. doi: 10.1182/blood-2002-08-2509. Epub 2003 Mar 6. Blood. 2003. PMID: 12623852 - Comprehensive methylome map of lineage commitment from haematopoietic progenitors.
Ji H, Ehrlich LI, Seita J, Murakami P, Doi A, Lindau P, Lee H, Aryee MJ, Irizarry RA, Kim K, Rossi DJ, Inlay MA, Serwold T, Karsunky H, Ho L, Daley GQ, Weissman IL, Feinberg AP. Ji H, et al. Nature. 2010 Sep 16;467(7313):338-42. doi: 10.1038/nature09367. Epub 2010 Aug 15. Nature. 2010. PMID: 20720541 Free PMC article. - Lineage promiscuity and plasticity in hematopoietic development.
Akashi K. Akashi K. Ann N Y Acad Sci. 2005 Jun;1044:125-31. doi: 10.1196/annals.1349.016. Ann N Y Acad Sci. 2005. PMID: 15958705 Review. - Biological and molecular evidence for existence of lymphoid-primed multipotent progenitors.
Luc S, Buza-Vidas N, Jacobsen SE. Luc S, et al. Ann N Y Acad Sci. 2007 Jun;1106:89-94. doi: 10.1196/annals.1392.023. Epub 2007 Apr 18. Ann N Y Acad Sci. 2007. PMID: 17442777 Review.
Cited by
- Wnt regulation of hematopoietic stem cell development and disease.
Carpenter KA, Thurlow KE, Craig SEL, Grainger S. Carpenter KA, et al. Curr Top Dev Biol. 2023;153:255-279. doi: 10.1016/bs.ctdb.2022.12.001. Epub 2023 Jan 9. Curr Top Dev Biol. 2023. PMID: 36967197 Free PMC article. Review. - The first embryo, the origin of cancer and animal phylogeny. I. A presentation of the neoplastic process and its connection with cell fusion and germline formation.
Cofre J, Saalfeld K. Cofre J, et al. Front Cell Dev Biol. 2023 Jan 4;10:1067248. doi: 10.3389/fcell.2022.1067248. eCollection 2022. Front Cell Dev Biol. 2023. PMID: 36684435 Free PMC article. - How Azanucleosides Affect Myeloid Cell Fate.
Stein A, Platzbecker U, Cross M. Stein A, et al. Cells. 2022 Aug 19;11(16):2589. doi: 10.3390/cells11162589. Cells. 2022. PMID: 36010665 Free PMC article. Review. - Neutrophil Homeostasis and Emergency Granulopoiesis: The Example of Systemic Juvenile Idiopathic Arthritis.
Malengier-Devlies B, Metzemaekers M, Wouters C, Proost P, Matthys P. Malengier-Devlies B, et al. Front Immunol. 2021 Dec 13;12:766620. doi: 10.3389/fimmu.2021.766620. eCollection 2021. Front Immunol. 2021. PMID: 34966386 Free PMC article. Review. - Prostaglandin E2 Regulates Bipotent Monocyte-Dendritic Progenitor Cell Lineage-Commitment.
Singh P, Pelus LM. Singh P, et al. Stem Cell Rev Rep. 2021 Dec;17(6):2338-2346. doi: 10.1007/s12015-021-10202-1. Epub 2021 Jun 22. Stem Cell Rev Rep. 2021. PMID: 34159458
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Molecular Biology Databases
Miscellaneous