Review: IFN-alpha/beta receptor interactions to biologic outcomes: understanding the circuitry - PubMed (original) (raw)
Review
Review: IFN-alpha/beta receptor interactions to biologic outcomes: understanding the circuitry
Melissa M Brierley et al. J Interferon Cytokine Res. 2002 Aug.
Abstract
Type I interferons (IFNs), which include the IFN-alphas, IFN-beta, IFN-omega, IFN-kappa, and IFN-tau, are an evolutionarily conserved group of secreted cytokines that serve as potent extracellular mediators of host defense and homeostasis. Binding of IFNs to specific cell surface receptors results in the activation of multiple intracellular signaling cascades, leadingto the synthesis of proteins that mediate antiviral, growth inhibitory and immunomodulatory responses. In the past decade, considerable information has accumulated pertaining to the different signalingpathways that are activated by the type I IFNs. Although many of the literature findings are specific to defined cell systems or are tissue restricted, the intent of this review is to place these signaling cascades and their effectors in the context of distinct biologic outcomes.
Similar articles
- Interferons, interferon-like cytokines, and their receptors.
Pestka S, Krause CD, Walter MR. Pestka S, et al. Immunol Rev. 2004 Dec;202:8-32. doi: 10.1111/j.0105-2896.2004.00204.x. Immunol Rev. 2004. PMID: 15546383 Review. - Hepatitis C virus replication in mouse cells is restricted by IFN-dependent and -independent mechanisms.
Nandakumar R, Finsterbusch K, Lipps C, Neumann B, Grashoff M, Nair S, Hochnadel I, Lienenklaus S, Wappler I, Steinmann E, Hauser H, Pietschmann T, Kröger A. Nandakumar R, et al. Gastroenterology. 2013 Dec;145(6):1414-23.e1. doi: 10.1053/j.gastro.2013.08.037. Epub 2013 Aug 21. Gastroenterology. 2013. PMID: 23973921 - Human interferons alpha, beta and omega.
Bekisz J, Schmeisser H, Hernandez J, Goldman ND, Zoon KC. Bekisz J, et al. Growth Factors. 2004 Dec;22(4):243-51. doi: 10.1080/08977190400000833. Growth Factors. 2004. PMID: 15621727 Review. - Transcription factors in interferon signaling.
David M. David M. Pharmacol Ther. 1995 Feb;65(2):149-61. doi: 10.1016/0163-7258(94)00050-d. Pharmacol Ther. 1995. PMID: 7540766 Review. - Interferon signalling network in innate defence.
Takaoka A, Yanai H. Takaoka A, et al. Cell Microbiol. 2006 Jun;8(6):907-22. doi: 10.1111/j.1462-5822.2006.00716.x. Cell Microbiol. 2006. PMID: 16681834 Review.
Cited by
- Intrapulmonary Versus Nasal Transduction of Murine Airways With GP64-pseudotyped Viral Vectors.
Oakland M, Maury W, McCray PB Jr, Sinn PL. Oakland M, et al. Mol Ther Nucleic Acids. 2013 Jan 29;2(1):e69. doi: 10.1038/mtna.2012.60. Mol Ther Nucleic Acids. 2013. PMID: 23360952 Free PMC article. - Epstein-Barr virus latent membrane protein LMP-2A is sufficient for transactivation of the human endogenous retrovirus HERV-K18 superantigen.
Sutkowski N, Chen G, Calderon G, Huber BT. Sutkowski N, et al. J Virol. 2004 Jul;78(14):7852-60. doi: 10.1128/JVI.78.14.7852-7860.2004. J Virol. 2004. PMID: 15220463 Free PMC article. - INTERFEROME: the database of interferon regulated genes.
Samarajiwa SA, Forster S, Auchettl K, Hertzog PJ. Samarajiwa SA, et al. Nucleic Acids Res. 2009 Jan;37(Database issue):D852-7. doi: 10.1093/nar/gkn732. Epub 2008 Nov 7. Nucleic Acids Res. 2009. PMID: 18996892 Free PMC article. - Poly(I:C) potentiates Bacillus Calmette-Guérin immunotherapy for bladder cancer.
Ayari C, Besançon M, Bergeron A, LaRue H, Bussières V, Fradet Y. Ayari C, et al. Cancer Immunol Immunother. 2016 Feb;65(2):223-34. doi: 10.1007/s00262-015-1789-y. Epub 2016 Jan 12. Cancer Immunol Immunother. 2016. PMID: 26759009 Free PMC article. - Receptor dimer stabilization by hierarchical plasma membrane microcompartments regulates cytokine signaling.
You C, Marquez-Lago TT, Richter CP, Wilmes S, Moraga I, Garcia KC, Leier A, Piehler J. You C, et al. Sci Adv. 2016 Dec 2;2(12):e1600452. doi: 10.1126/sciadv.1600452. eCollection 2016 Dec. Sci Adv. 2016. PMID: 27957535 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous