Reversal of bone loss in mice by nongenotropic signaling of sex steroids - PubMed (original) (raw)
. 2002 Oct 25;298(5594):843-6.
doi: 10.1126/science.1074935.
J R Chen, T Bellido, L Han, A A Ali, C A O'Brien, L Plotkin, Q Fu, A T Mancino, Y Wen, A M Vertino, C C Powers, S A Stewart, R Ebert, A M Parfitt, R S Weinstein, R L Jilka, S C Manolagas
Affiliations
- PMID: 12399595
- DOI: 10.1126/science.1074935
Reversal of bone loss in mice by nongenotropic signaling of sex steroids
S Kousteni et al. Science. 2002.
Erratum in
- Science. 2003 Feb 21;299(5610):1184
Abstract
We show that sex steroids protect the adult murine skeleton through a mechanism that is distinct from that used to preserve the mass and function of reproductive organs. The classical genotropic actions of sex steroid receptors are dispensable for their bone protective effects, but essential for their effects on reproductive tissues. A synthetic ligand (4-estren-3alpha,17beta-diol) that reproduces the nongenotropic effects of sex steroids, without affecting classical transcription, increases bone mass and strength in ovariectomized females above the level of the estrogen-replete state and is at least as effective as dihydrotestosterone in orchidectomized males, without affecting reproductive organs. Such ligands merit investigation as potential therapeutic alternatives to hormone replacement for osteoporosis in both women and men [corrected].
Comment in
- Endocrinology. Divorcing estrogen's bright and dark sides.
Miller G. Miller G. Science. 2002 Oct 25;298(5594):723-4. doi: 10.1126/science.298.5594.723a. Science. 2002. PMID: 12399556 No abstract available.
Similar articles
- Endocrinology. Divorcing estrogen's bright and dark sides.
Miller G. Miller G. Science. 2002 Oct 25;298(5594):723-4. doi: 10.1126/science.298.5594.723a. Science. 2002. PMID: 12399556 No abstract available. - Estren is a selective estrogen receptor modulator with transcriptional activity.
Movérare S, Dahllund J, Andersson N, Islander U, Carlsten H, Gustafsson JA, Nilsson S, Ohlsson C. Movérare S, et al. Mol Pharmacol. 2003 Dec;64(6):1428-33. doi: 10.1124/mol.64.6.1428. Mol Pharmacol. 2003. PMID: 14645673 - A comparative study of the effects of genistein, estradiol and raloxifene on the murine skeletal system.
Sliwiński L, Folwarczna J, Nowińska B, Cegieła U, Pytlik M, Kaczmarczyk-Sedlak I, Trzeciak H, Trzeciak HI. Sliwiński L, et al. Acta Biochim Pol. 2009;56(2):261-70. Epub 2009 Apr 30. Acta Biochim Pol. 2009. PMID: 19401787 - Sex steroids and bone.
Manolagas SC, Kousteni S, Jilka RL. Manolagas SC, et al. Recent Prog Horm Res. 2002;57:385-409. doi: 10.1210/rp.57.1.385. Recent Prog Horm Res. 2002. PMID: 12017554 Review. - Kinase-mediated transcription, activators of nongenotropic estrogen-like signaling (ANGELS), and osteoporosis: a different perspective on the HRT dilemma.
Manolagas SC, Kousteni S, Chen JR, Schuller M, Plotkin L, Bellido T. Manolagas SC, et al. Kidney Int Suppl. 2004 Oct;(91):S41-9. doi: 10.1111/j.1523-1755.2004.09107.x. Kidney Int Suppl. 2004. PMID: 15461702 Review.
Cited by
- Sexual Dimorphism in the Musculoskeletal System: Sex Hormones and Beyond.
Plotkin LI, Bruzzaniti A, Pianeta R. Plotkin LI, et al. J Endocr Soc. 2024 Sep 1;8(10):bvae153. doi: 10.1210/jendso/bvae153. eCollection 2024 Aug 27. J Endocr Soc. 2024. PMID: 39309123 Free PMC article. Review. - Insights and implications of sexual dimorphism in osteoporosis.
Zhang YY, Xie N, Sun XD, Nice EC, Liou YC, Huang C, Zhu H, Shen Z. Zhang YY, et al. Bone Res. 2024 Feb 18;12(1):8. doi: 10.1038/s41413-023-00306-4. Bone Res. 2024. PMID: 38368422 Free PMC article. Review. - From the Mind to the Spine: The Intersecting World of Alzheimer's and Osteoporosis.
Margetts TJ, Wang HS, Karnik SJ, Plotkin LI, Movila A, Oblak AL, Fehrenbacher JC, Kacena MA. Margetts TJ, et al. Curr Osteoporos Rep. 2024 Feb;22(1):152-164. doi: 10.1007/s11914-023-00848-w. Epub 2024 Feb 9. Curr Osteoporos Rep. 2024. PMID: 38334917 Free PMC article. Review. - Is Hormone Replacement Therapy a Risk Factor or a Therapeutic Option for Alzheimer's Disease?
Mills ZB, Faull RLM, Kwakowsky A. Mills ZB, et al. Int J Mol Sci. 2023 Feb 6;24(4):3205. doi: 10.3390/ijms24043205. Int J Mol Sci. 2023. PMID: 36834617 Free PMC article. Review. - Fracture Healing in the Setting of Endocrine Diseases, Aging, and Cellular Senescence.
Saul D, Khosla S. Saul D, et al. Endocr Rev. 2022 Nov 25;43(6):984-1002. doi: 10.1210/endrev/bnac008. Endocr Rev. 2022. PMID: 35182420 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical