Evidence that Armadillo transduces wingless by mediating nuclear export or cytosolic activation of Pangolin - PubMed (original) (raw)
Evidence that Armadillo transduces wingless by mediating nuclear export or cytosolic activation of Pangolin
Siu-Kwong Chan et al. Cell. 2002.
Free article
Erratum in
- Cell. 2003 Jul 25;114(2):267
Retraction in
- Evidence that Armadillo transduces wingless by mediating nuclear export or cytosolic activation of Pangolin.
Struhl G. Struhl G. Cell. 2004 Feb 6;116(3):481. doi: 10.1016/s0092-8674(04)00122-9. Cell. 2004. PMID: 15025097 No abstract available.
Abstract
Secreted proteins of the Wnt family have profound organizing roles during animal development and are transduced via the activities of the Frizzled (Fz) class of transmembrane receptors and the TCF/LEF/Pangolin class of transcription factors. beta-catenins, including Drosophila Armadillo (Arm), link activation of Fz at the cell surface to transcriptional regulation by TCF in the nucleus. The consensus view is that Wnt signaling induces beta-catenin to enter the nucleus and combine with TCF to form a transcription factor complex in which TCF binds DNA and the C-terminal domain of beta-catenin activates transcription. Here, we present findings, which challenge this view and suggest instead that beta-catenin may transduce Wnt signals by exporting TCF from the nucleus or activating it in the cytoplasm.
Similar articles
- pangolin encodes a Lef-1 homologue that acts downstream of Armadillo to transduce the Wingless signal in Drosophila.
Brunner E, Peter O, Schweizer L, Basler K. Brunner E, et al. Nature. 1997 Feb 27;385(6619):829-33. doi: 10.1038/385829a0. Nature. 1997. PMID: 9039917 - Membrane-tethered Drosophila Armadillo cannot transduce Wingless signal on its own.
Cox RT, Pai LM, Miller JR, Orsulic S, Stein J, McCormick CA, Audeh Y, Wang W, Moon RT, Peifer M. Cox RT, et al. Development. 1999 Mar;126(6):1327-35. doi: 10.1242/dev.126.6.1327. Development. 1999. PMID: 10021350 - Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex.
Kramps T, Peter O, Brunner E, Nellen D, Froesch B, Chatterjee S, Murone M, Züllig S, Basler K. Kramps T, et al. Cell. 2002 Apr 5;109(1):47-60. doi: 10.1016/s0092-8674(02)00679-7. Cell. 2002. PMID: 11955446 - The control of beta-catenin and TCF during embryonic development and cancer.
Waltzer L, Bienz M. Waltzer L, et al. Cancer Metastasis Rev. 1999;18(2):231-46. doi: 10.1023/a:1006321324190. Cancer Metastasis Rev. 1999. PMID: 10728986 Review. - TCF transcription factors: molecular switches in carcinogenesis.
Roose J, Clevers H. Roose J, et al. Biochim Biophys Acta. 1999 Oct 29;1424(2-3):M23-37. doi: 10.1016/s0304-419x(99)00026-8. Biochim Biophys Acta. 1999. PMID: 10528152 Review.
Cited by
- Identification and characterization of Wnt signaling pathway in keloid pathogenesis.
Igota S, Tosa M, Murakami M, Egawa S, Shimizu H, Hyakusoku H, Ghazizadeh M. Igota S, et al. Int J Med Sci. 2013;10(4):344-54. doi: 10.7150/ijms.5349. Epub 2013 Feb 15. Int J Med Sci. 2013. PMID: 23471552 Free PMC article. - Requirement for a nuclear function of beta-catenin in Wnt signaling.
Cong F, Schweizer L, Chamorro M, Varmus H. Cong F, et al. Mol Cell Biol. 2003 Dec;23(23):8462-70. doi: 10.1128/MCB.23.23.8462-8470.2003. Mol Cell Biol. 2003. PMID: 14612392 Free PMC article. - Nuclear β-catenin localization and mutation of the CTNNB1 gene: a context-dependent association.
Kim G, Kurnit KC, Djordjevic B, Singh C, Munsell MF, Wang WL, Lazar AJ, Zhang W, Broaddus R. Kim G, et al. Mod Pathol. 2018 Oct;31(10):1553-1559. doi: 10.1038/s41379-018-0080-0. Epub 2018 May 24. Mod Pathol. 2018. PMID: 29795437 Free PMC article. - Beta-catenin regulation during the cell cycle: implications in G2/M and apoptosis.
Olmeda D, Castel S, Vilaró S, Cano A. Olmeda D, et al. Mol Biol Cell. 2003 Jul;14(7):2844-60. doi: 10.1091/mbc.e03-01-0865. Epub 2003 Apr 4. Mol Biol Cell. 2003. PMID: 12857869 Free PMC article. - Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation.
Topol L, Jiang X, Choi H, Garrett-Beal L, Carolan PJ, Yang Y. Topol L, et al. J Cell Biol. 2003 Sep 1;162(5):899-908. doi: 10.1083/jcb.200303158. J Cell Biol. 2003. PMID: 12952940 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases