Ca2+/cAMP response element-binding protein (CREB)-dependent activation of Per1 is required for light-induced signaling in the suprachiasmatic nucleus circadian clock - PubMed (original) (raw)
. 2003 Jan 10;278(2):718-23.
doi: 10.1074/jbc.M209241200. Epub 2002 Oct 29.
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- PMID: 12409294
- DOI: 10.1074/jbc.M209241200
Free article
Ca2+/cAMP response element-binding protein (CREB)-dependent activation of Per1 is required for light-induced signaling in the suprachiasmatic nucleus circadian clock
Shelley A Tischkau et al. J Biol Chem. 2003.
Free article
Abstract
Light is a prominent stimulus that synchronizes endogenous circadian rhythmicity to environmental light/dark cycles. Nocturnal light elevates mRNA of the Period1 (Per1) gene and induces long term state changes, expressed as phase shifts of circadian rhythms. The cellular mechanism for Per1 elevation and light-induced phase advance in the suprachiasmatic nucleus (SCN), a process initiated primarily by glutamatergic neurotransmission from the retinohypothalamic tract, was examined. Glutamate (GLU)-induced phase advances in the rat SCN were blocked by antisense oligodeoxynucleotide (ODN) against Per1 and Ca(2+)/cAMP response element (CRE)-decoy ODN. CRE-decoy ODN also blocked light-induced phase advances in vivo. Furthermore, the CRE-decoy blocked GLU-induced accumulation of Per1 mRNA. Thus, Ca(2+)/cAMP response element-binding protein (CREB) and Per1 are integral components of the pathway transducing light-stimulated GLU neurotransmission into phase advance of the circadian clock.
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- R01 NS022155/NS/NINDS NIH HHS/United States
- MH12351/MH/NIMH NIH HHS/United States
- HL67007/HL/NHLBI NIH HHS/United States
- NS22155/NS/NINDS NIH HHS/United States
- NS11158/NS/NINDS NIH HHS/United States
- NS10170/NS/NINDS NIH HHS/United States
- R01 HL067007/HL/NHLBI NIH HHS/United States
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