RNASEL Arg462Gln variant is implicated in up to 13% of prostate cancer cases - PubMed (original) (raw)

Comparative Study

doi: 10.1038/ng1021. Epub 2002 Nov 4.

Phillippa J Neville, Sarah J Plummer, Ying Xiang, Lisa M Krumroy, Eric A Klein, William J Catalona, Nina Nupponen, John D Carpten, Jeffrey M Trent, Robert H Silverman, John S Witte

Affiliations

Comparative Study

RNASEL Arg462Gln variant is implicated in up to 13% of prostate cancer cases

Graham Casey et al. Nat Genet. 2002 Dec.

Abstract

RNASEL (encoding ribonuclease L) has recently been proposed as a candidate for the hereditary prostate cancer (HPC1) gene. We determined that the RNASEL variant Arg462Gln has three times less enzymatic activity than the wildtype and is significantly associated with prostate cancer risk (P = 0.007). At least one copy of the mutated allele that causes this substitution is carried by nearly 60% of the men in our study. Men that are heterozygous with respect to the mutated allele have 50% greater risk of prostate cancer than non-carriers, and homozygotes have more than double the risk.

PubMed Disclaimer

Comment in

Publication types

MeSH terms

Substances

LinkOut - more resources