The immunology of susceptibility and resistance to Leishmania major in mice - PubMed (original) (raw)
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doi: 10.1038/nri933.
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- PMID: 12415308
- DOI: 10.1038/nri933
Review
The immunology of susceptibility and resistance to Leishmania major in mice
David Sacks et al. Nat Rev Immunol. 2002 Nov.
Abstract
Established models of T-helper-2-cell dominance in BALB/c mice infected with Leishmania major -- involving the early production of interleukin-4 by a small subset of Leishmania-specific CD4+ T cells -- have been refined by accumulating evidence that this response is not sufficient and, under some circumstances, not required to promote susceptibility. In addition, more recent studies in L. major-resistant mice have revealed complexities in the mechanisms responsible for acquired immunity, which necessitate the redesign of vaccines against Leishmania and other pathogens that require sustained cell-mediated immune responses.
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