The Salmonella enterica subspecies I specific centisome 7 genomic island encodes novel protein families present in bacteria living in close contact with eukaryotic cells - PubMed (original) (raw)
The Salmonella enterica subspecies I specific centisome 7 genomic island encodes novel protein families present in bacteria living in close contact with eukaryotic cells
Anders Folkesson et al. Res Microbiol. 2002 Oct.
Free article
Abstract
We have determined the genetic structure of the Salmonella enterica centisome 7 genomic island (SCI) located at the aspV loci in S. enterica subspecies I strains. The 47-kb long genomic island encodes 37 putative proteins, including the previously described saf fimbrial operon and the sinR transcriptional regulator. Other open reading frames (designated sci A to Z) in the island encode putative proteins with homologies to virulence-associated proteins in a number of gram-negative bacteria such as Pseudomonas aeruginosa, Yersinia pestis and enterohemorrhagic Escherichia coli, bacteria that have the ability to interact with and manipulate eukaryotic cells. The Sci proteins have putative cytoplasmic, periplasmic and outer membrane localizations pointing to a role in extracellular processes such as secretion or organelle biosynthesis. The genes encoding Sci-like proteins are clustered in all sequenced bacterial genomes available in the databases and a core set can be defined by the presence of genes encoding proteins with similarity to the SciB, C, G, H, I, O proteins. The SCI genomic island DNA sequences are restricted to Salmonella strains belonging to S. enterica subspecies I and deletion of the entire island affects the ability of the organisms to enter eukaryotic cells.
Similar articles
- Multiple insertions of fimbrial operons correlate with the evolution of Salmonella serovars responsible for human disease.
Folkesson A, Advani A, Sukupolvi S, Pfeifer JD, Normark S, Löfdahl S. Folkesson A, et al. Mol Microbiol. 1999 Aug;33(3):612-22. doi: 10.1046/j.1365-2958.1999.01508.x. Mol Microbiol. 1999. PMID: 10417651 - Salmonella typhimurium encodes a putative iron transport system within the centisome 63 pathogenicity island.
Zhou D, Hardt WD, Galán JE. Zhou D, et al. Infect Immun. 1999 Apr;67(4):1974-81. doi: 10.1128/IAI.67.4.1974-1981.1999. Infect Immun. 1999. PMID: 10085045 Free PMC article. - Nucleotide sequence of a 13.9 kb segment of the 90 kb virulence plasmid of Salmonella typhimurium: the presence of fimbrial biosynthetic genes.
Friedrich MJ, Kinsey NE, Vila J, Kadner RJ. Friedrich MJ, et al. Mol Microbiol. 1993 May;8(3):543-58. doi: 10.1111/j.1365-2958.1993.tb01599.x. Mol Microbiol. 1993. PMID: 8100983 - Genomic subtraction identifies Salmonella typhimurium prophages, F-related plasmid sequences, and a novel fimbrial operon, stf, which are absent in Salmonella typhi.
Emmerth M, Goebel W, Miller SI, Hueck CJ. Emmerth M, et al. J Bacteriol. 1999 Sep;181(18):5652-61. doi: 10.1128/JB.181.18.5652-5661.1999. J Bacteriol. 1999. PMID: 10482505 Free PMC article.
Cited by
- Identification of a conserved bacterial protein secretion system in Vibrio cholerae using the Dictyostelium host model system.
Pukatzki S, Ma AT, Sturtevant D, Krastins B, Sarracino D, Nelson WC, Heidelberg JF, Mekalanos JJ. Pukatzki S, et al. Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1528-33. doi: 10.1073/pnas.0510322103. Epub 2006 Jan 23. Proc Natl Acad Sci U S A. 2006. PMID: 16432199 Free PMC article. - Selection of orphan Rhs toxin expression in evolved Salmonella enterica serovar Typhimurium.
Koskiniemi S, Garza-Sánchez F, Sandegren L, Webb JS, Braaten BA, Poole SJ, Andersson DI, Hayes CS, Low DA. Koskiniemi S, et al. PLoS Genet. 2014 Mar 27;10(3):e1004255. doi: 10.1371/journal.pgen.1004255. eCollection 2014 Mar. PLoS Genet. 2014. PMID: 24675981 Free PMC article. - Genome sequence of Cronobacter sakazakii BAA-894 and comparative genomic hybridization analysis with other Cronobacter species.
Kucerova E, Clifton SW, Xia XQ, Long F, Porwollik S, Fulton L, Fronick C, Minx P, Kyung K, Warren W, Fulton R, Feng D, Wollam A, Shah N, Bhonagiri V, Nash WE, Hallsworth-Pepin K, Wilson RK, McClelland M, Forsythe SJ. Kucerova E, et al. PLoS One. 2010 Mar 8;5(3):e9556. doi: 10.1371/journal.pone.0009556. PLoS One. 2010. PMID: 20221447 Free PMC article. - The Vibrio Cholerae Type VI Secretion System: Evaluating its Role in the Human Disease Cholera.
Miyata ST, Kitaoka M, Wieteska L, Frech C, Chen N, Pukatzki S. Miyata ST, et al. Front Microbiol. 2010 Nov 15;1:117. doi: 10.3389/fmicb.2010.00117. eCollection 2010. Front Microbiol. 2010. PMID: 21607085 Free PMC article. - H-NS Silencing of the Salmonella Pathogenicity Island 6-Encoded Type VI Secretion System Limits Salmonella enterica Serovar Typhimurium Interbacterial Killing.
Brunet YR, Khodr A, Logger L, Aussel L, Mignot T, Rimsky S, Cascales E. Brunet YR, et al. Infect Immun. 2015 Jul;83(7):2738-50. doi: 10.1128/IAI.00198-15. Epub 2015 Apr 27. Infect Immun. 2015. PMID: 25916986 Free PMC article.