Replacing the nucleobases in DNA with designer molecules - PubMed (original) (raw)

Review

. 2002 Nov;35(11):936-43.

doi: 10.1021/ar000183u.

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• PMID: 12437318
• DOI: 10.1021/ar000183u

Review

Replacing the nucleobases in DNA with designer molecules

Eric T Kool. Acc Chem Res. 2002 Nov.

Abstract

DNA is not only a carrier of genetic information, but it is also a versatile supramolecular scaffold, arranging smaller organic structures into predesigned geometries. Herein are discussed molecular strategies in which the natural DNA bases on the sugar-phosphate backbone are replaced by other molecules. Some of the base replacements under study include fluorophores, ligands for metals, helix stabilizers, and DNA base shape mimics.

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