Evidence for a hereditary neuroblastoma predisposition locus at chromosome 16p12-13 - PubMed (original) (raw)

. 2002 Nov 15;62(22):6651-8.

Matthew J Weiss, Yael Mosse, George Hii, Chun Guo, Peter S White, Michael D Hogarty, Tamar Mirensky, Garrett M Brodeur, Timothy R Rebbeck, Margrit Urbanek, Suzanne Shusterman

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Evidence for a hereditary neuroblastoma predisposition locus at chromosome 16p12-13

John M Maris et al. Cancer Res. 2002.

Abstract

Hereditary predisposition to develop neuroblastoma (Online Mendelian Inheritance in Man 256700), a pediatric cancer of the sympathetic nervous system, segregates as an autosomal dominant Mendelian trait. We performed linkage analysis on seven families with two or more first-degree relatives affected with neuroblastoma to localize a hereditary neuroblastoma predisposition gene. A single interval at chromosome bands 16p12-13 was the only genomic region consistent with linkage (LOD(MAX) = 3.30 at D16S764). Identification of informative recombination events in linked families defined a 28.0-cM region between D16S748 and D16S769 that cosegregated with the disease in each pedigree. Loss of heterozygosity was identified in 5 of 11 familial neuroblastomas and 68 of 336 nonfamilial neuroblastomas (20.2%) at multiple 16p polymorphic loci. A 14.5-cM smallest region of overlap of somatic deletions was identified within the interval defined by linkage analysis (tel-D16S500-D16S412-cen). Taken together, these data suggest that a hereditary neuroblastoma predisposition gene (HNB1) is located at 16p12-13 and that disruption of this gene may contribute to the pathogenesis of nonfamilial neuroblastomas.

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