Genes involved in breast cancer metastasis to bone - PubMed (original) (raw)
Review
Genes involved in breast cancer metastasis to bone
E K I Sloan et al. Cell Mol Life Sci. 2002 Sep.
Abstract
Metastasis to bone occurs frequently in advanced breast cancer and is accompanied by debilitating skeletal complications. Current treatments are palliative and new therapies that specifically prevent the spread of breast cancer to bone are urgently required. While our understanding of interactions between breast cancer cells and bone cells has greatly improved, we still know little about the molecular determinants that regulate specific homing of breast cancer cells to the bone. In this review, we focus on genes that have been implicated in migration and adhesion of breast cancer cells to bone, as well as genes that promote tumor cell proliferation in the bone microenvironment. In addition, the review discusses new technologies, including better animal models, that will further assist with the identification of the molecular determinants of bone metastasis and will guide the development of new therapies.
Similar articles
- Cellular and molecular basis of preferential metastasis of breast cancer to bone.
Yoneda T. Yoneda T. J Orthop Sci. 2000;5(1):75-81. doi: 10.1007/s007760050012. J Orthop Sci. 2000. PMID: 10664443 Review. - Bone sialoprotein-αvβ3 integrin axis promotes breast cancer metastasis to the bone.
Wang L, Song L, Li J, Wang Y, Yang C, Kou X, Xiao B, Zhang W, Li L, Liu S, Wang J. Wang L, et al. Cancer Sci. 2019 Oct;110(10):3157-3172. doi: 10.1111/cas.14172. Epub 2019 Sep 5. Cancer Sci. 2019. PMID: 31432600 Free PMC article. - Breast cancer osteomimicry and its role in bone specific metastasis; an integrative, systematic review of preclinical evidence.
Awolaran O, Brooks SA, Lavender V. Awolaran O, et al. Breast. 2016 Dec;30:156-171. doi: 10.1016/j.breast.2016.09.017. Epub 2016 Oct 14. Breast. 2016. PMID: 27750106 Review. - MicroRNAs and Their Roles in Breast Cancer Bone Metastasis.
Puppo M, Valluru MK, Clézardin P. Puppo M, et al. Curr Osteoporos Rep. 2021 Jun;19(3):256-263. doi: 10.1007/s11914-021-00677-9. Epub 2021 Apr 8. Curr Osteoporos Rep. 2021. PMID: 33830428 Free PMC article. Review. - Leptin promotes bone metastasis of breast cancer by activating the SDF-1/CXCR4 axis.
Duan L, Lu Y, Xie W, Nong L, Jia Y, Tan A, Liu Y. Duan L, et al. Aging (Albany NY). 2020 Aug 18;12(16):16172-16182. doi: 10.18632/aging.103599. Epub 2020 Aug 18. Aging (Albany NY). 2020. PMID: 32836215 Free PMC article.
Cited by
- The anti-migration and anti-invasion effects of Bruceine D in human triple-negative breast cancer MDA-MB-231 cells.
Luo C, Wang Y, Wei C, Chen Y, Ji Z. Luo C, et al. Exp Ther Med. 2020 Jan;19(1):273-279. doi: 10.3892/etm.2019.8187. Epub 2019 Nov 12. Exp Ther Med. 2020. PMID: 31853299 Free PMC article. - Metastasis movies, macrophages, molecules and more. Conference on Mechanisms of Invasion and Metastasis.
Montell D. Montell D. EMBO Rep. 2003 May;4(5):458-62. doi: 10.1038/sj.embor.embor829. EMBO Rep. 2003. PMID: 12704425 Free PMC article. - A small molecule antagonist of the alpha(v)beta3 integrin suppresses MDA-MB-435 skeletal metastasis.
Harms JF, Welch DR, Samant RS, Shevde LA, Miele ME, Babu GR, Goldberg SF, Gilman VR, Sosnowski DM, Campo DA, Gay CV, Budgeon LR, Mercer R, Jewell J, Mastro AM, Donahue HJ, Erin N, Debies MT, Meehan WJ, Jones AL, Mbalaviele G, Nickols A, Christensen ND, Melly R, Beck LN, Kent J, Rader RK, Kotyk JJ, Pagel MD, Westlin WF, Griggs DW. Harms JF, et al. Clin Exp Metastasis. 2004;21(2):119-28. doi: 10.1023/b:clin.0000024763.69809.64. Clin Exp Metastasis. 2004. PMID: 15168729 - Homing of cancer cells to the bone.
Mishra A, Shiozawa Y, Pienta KJ, Taichman RS. Mishra A, et al. Cancer Microenviron. 2011 Dec;4(3):221-35. doi: 10.1007/s12307-011-0083-6. Epub 2011 Aug 9. Cancer Microenviron. 2011. PMID: 21826451 Free PMC article. - Oncostatin m promotes mammary tumor metastasis to bone and osteolytic bone degradation.
Bolin C, Tawara K, Sutherland C, Redshaw J, Aranda P, Moselhy J, Anderson R, Jorcyk CL. Bolin C, et al. Genes Cancer. 2012 Feb;3(2):117-30. doi: 10.1177/1947601912458284. Genes Cancer. 2012. PMID: 23050044 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical