Loss of myostatin attenuates severity of muscular dystrophy in mdx mice - PubMed (original) (raw)

Comparative Study

doi: 10.1002/ana.10385.

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• PMID: 12447939
• DOI: 10.1002/ana.10385

Comparative Study

Loss of myostatin attenuates severity of muscular dystrophy in mdx mice

Kathryn R Wagner et al. Ann Neurol. 2002 Dec.

Abstract

Myostatin, a transforming growth factor-beta family member, is a negative regulator of skeletal muscle growth. To explore the therapeutic potential of targeting myostatin in settings of muscle degeneration, we crossed myostatin null mutant mice with mdx mice, a model for Duchenne and Becker muscular dystrophy. Mdx mice lacking myostatin were stronger and more muscular than their mdx counterparts. Diaphragm muscle showed less fibrosis and fatty remodeling, suggesting improved muscle regeneration.

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