Comparison of the antioxidant effects of Concord grape juice flavonoids alpha-tocopherol on markers of oxidative stress in healthy adults - PubMed (original) (raw)
Clinical Trial
. 2002 Dec;76(6):1367-74.
doi: 10.1093/ajcn/76.6.1367.
Affiliations
- PMID: 12450905
- DOI: 10.1093/ajcn/76.6.1367
Clinical Trial
Comparison of the antioxidant effects of Concord grape juice flavonoids alpha-tocopherol on markers of oxidative stress in healthy adults
Dawn J O'Byrne et al. Am J Clin Nutr. 2002 Dec.
Abstract
Background: Concord grape juice (CGJ) is a rich source of flavonoids, which have greater antioxidant efficacy in vitro than does alpha-tocopherol; however, the efficacies of flavonoids and alpha-tocopherol in vivo have not been compared.
Objective: We compared the in vivo antioxidant efficacy of CGJ with that of alpha-tocopherol in healthy adults.
Design: Subjects were randomly assigned to receive either 400 IU RRR-alpha-tocopherol/d (n = 17) or 10 mL CGJ. kg(-1). d(-1) (n = 15) for 2 wk. Serum oxygen radical absorbance capacity, plasma protein carbonyls, urinary F(2)-isoprostanes, and resistance of LDL to ex vivo oxidation were measured before and after supplementation as markers of antioxidant status and oxidative stress.
Results: After supplementation, plasma alpha-tocopherol increased 92% in subjects who received alpha-tocopherol (P < 0.001); plasma total and conjugated phenols increased 17% (P < 0.01) and 22% (P < 0.001), respectively, in subjects who received CGJ. There was a significant change in plasma triacylglycerols in both groups, but the concentrations were within the normal range. CGJ supplementation was associated with significantly higher triacylglycerols than was alpha-tocopherol supplementation. Both supplementation regimens significantly increased serum oxygen radical absorbance capacity (P < 0.001) and LDL lag time (P < 0.001) and significantly decreased the LDL oxidation rate (P < 0.01), with no significant difference in effectiveness. Protein carbonyl concentrations in native plasma decreased 20% after CGJ supplementation, which was a significantly different response than that after alpha-tocopherol supplementation (P < 0.05).
Conclusions: In healthy adults, 10 mL CGJ. kg(-1). d(-1) increased serum antioxidant capacity and protected LDL against oxidation to an extent similar to that obtained with 400 IU alpha-tocopherol/d but decreased native plasma protein oxidation significantly more than did alpha-tocopherol. CGJ flavonoids are potent antioxidants that may protect against oxidative stress and reduce the risk of free radical damage and chronic diseases.
Similar articles
- Comparison of the effect of alpha-lipoic acid and alpha-tocopherol supplementation on measures of oxidative stress.
Marangon K, Devaraj S, Tirosh O, Packer L, Jialal I. Marangon K, et al. Free Radic Biol Med. 1999 Nov;27(9-10):1114-21. doi: 10.1016/s0891-5849(99)00155-0. Free Radic Biol Med. 1999. PMID: 10569644 Clinical Trial. - γ-Tocopherol-rich supplementation additively improves vascular endothelial function during smoking cessation.
Mah E, Pei R, Guo Y, Ballard KD, Barker T, Rogers VE, Parker BA, Taylor AW, Traber MG, Volek JS, Bruno RS. Mah E, et al. Free Radic Biol Med. 2013 Dec;65:1291-1299. doi: 10.1016/j.freeradbiomed.2013.09.016. Epub 2013 Sep 27. Free Radic Biol Med. 2013. PMID: 24075893 Clinical Trial. - Effects of concord grape juice on appetite, diet, body weight, lipid profile, and antioxidant status of adults.
Hollis JH, Houchins JA, Blumberg JB, Mattes RD. Hollis JH, et al. J Am Coll Nutr. 2009 Oct;28(5):574-82. doi: 10.1080/07315724.2009.10719789. J Am Coll Nutr. 2009. PMID: 20439553 Clinical Trial. - Grape polyphenols supplementation for exercise-induced oxidative stress.
Elejalde E, Villarán MC, Alonso RM. Elejalde E, et al. J Int Soc Sports Nutr. 2021 Jan 7;18(1):3. doi: 10.1186/s12970-020-00395-0. J Int Soc Sports Nutr. 2021. PMID: 33413451 Free PMC article. Review. - Potential antiatherogenic mechanisms of ascorbate (vitamin C) and alpha-tocopherol (vitamin E).
Carr AC, Zhu BZ, Frei B. Carr AC, et al. Circ Res. 2000 Sep 1;87(5):349-54. doi: 10.1161/01.res.87.5.349. Circ Res. 2000. PMID: 10969031 Review.
Cited by
- Natural antioxidants from some fruits, seeds, foods, natural products, and associated health benefits: An update.
Rahaman MM, Hossain R, Herrera-Bravo J, Islam MT, Atolani O, Adeyemi OS, Owolodun OA, Kambizi L, Daştan SD, Calina D, Sharifi-Rad J. Rahaman MM, et al. Food Sci Nutr. 2023 Jan 13;11(4):1657-1670. doi: 10.1002/fsn3.3217. eCollection 2023 Apr. Food Sci Nutr. 2023. PMID: 37051367 Free PMC article. Review. - In Vitro Experimental Assessment of Ethanolic Extract of Moringa oleifera Leaves as an _α_-Amylase and _α_-Lipase Inhibitor.
Ogundipe A, Adetuyi B, Iheagwam F, Adefoyeke K, Olugbuyiro J, Ogunlana O, Ogunlana O. Ogundipe A, et al. Biochem Res Int. 2022 Dec 29;2022:4613109. doi: 10.1155/2022/4613109. eCollection 2022. Biochem Res Int. 2022. PMID: 36620201 Free PMC article. - Elaboration of an organic beverage based on grape juice with positive nutritional properties.
Bendaali Y, Vaquero C, González C, Morata A. Bendaali Y, et al. Food Sci Nutr. 2022 Mar 11;10(6):1768-1779. doi: 10.1002/fsn3.2795. eCollection 2022 Jun. Food Sci Nutr. 2022. PMID: 35702314 Free PMC article. - Potential Associations among Bioactive Molecules, Antioxidant Activity and Resveratrol Production in Vitis vinifera Fruits of North America.
Wijekoon C, Netticadan T, Siow YL, Sabra A, Yu L, Raj P, Prashar S. Wijekoon C, et al. Molecules. 2022 Jan 6;27(2):336. doi: 10.3390/molecules27020336. Molecules. 2022. PMID: 35056651 Free PMC article. - Protective Effects of Grape Juice on Vascular Damage Induced by Chlorine Free Radical in Rats.
Junior JB, Arantes DAC, Siqueira Leite KC, de Souza Gil E, Rocha ML. Junior JB, et al. Prev Nutr Food Sci. 2021 Dec 31;26(4):417-424. doi: 10.3746/pnf.2021.26.4.417. Prev Nutr Food Sci. 2021. PMID: 35047438 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical