Cosegregation of chromosomes containing immortal DNA strands in cells that cycle with asymmetric stem cell kinetics - PubMed (original) (raw)

. 2002 Dec 1;62(23):6791-5.

Affiliations

• PMID: 12460886

Cosegregation of chromosomes containing immortal DNA strands in cells that cycle with asymmetric stem cell kinetics

Joshua R Merok et al. Cancer Res. 2002.

Abstract

A long-standing intriguing hypothesis in cancer biology is that adult stem cells avoid mutations from DNA replication errors by a unique pattern of chromosome segregation. At each asymmetric cell division, adult stem cells have been postulated to selectively retain a set of chromosomes that contain old template DNA strands (i.e., "immortal DNA strands"). Using cultured cells that cycle with asymmetric cell kinetics, we confirmed both the existence of immortal DNA strands and the cosegregation of chromosomes that bear them. Our findings also lead us to propose a role for immortal DNA strands in tissue aging as well as cancer.

PubMed Disclaimer

Similar articles

• Immortal DNA strand cosegregation requires p53/IMPDH-dependent asymmetric self-renewal associated with adult stem cells.
  Rambhatla L, Ram-Mohan S, Cheng JJ, Sherley JL. Rambhatla L, et al. Cancer Res. 2005 Apr 15;65(8):3155-61. doi: 10.1158/0008-5472.CAN-04-3161. Cancer Res. 2005. PMID: 15833845
• [Maintenance of genetic information in stem cells].
  Terskikh VV, Vasil'ev AV, Voroteliak EA. Terskikh VV, et al. Genetika. 2008 Mar;44(3):305-8. Genetika. 2008. PMID: 18664132 Review. Russian.
• Immortal strands? Give me a break.
  Lansdorp PM. Lansdorp PM. Cell. 2007 Jun 29;129(7):1244-7. doi: 10.1016/j.cell.2007.06.017. Cell. 2007. PMID: 17604711 Review.
• Stem cell identity and template DNA strand segregation.
  Tajbakhsh S. Tajbakhsh S. Curr Opin Cell Biol. 2008 Dec;20(6):716-22. doi: 10.1016/j.ceb.2008.10.004. Epub 2008 Nov 25. Curr Opin Cell Biol. 2008. PMID: 18996191 Review.
• Molecular cloaking of H2A.Z on mortal DNA chromosomes during nonrandom segregation.
  Huh YH, Sherley JL. Huh YH, et al. Stem Cells. 2011 Oct;29(10):1620-7. doi: 10.1002/stem.707. Stem Cells. 2011. PMID: 21905168

Cited by

• The universal stem cell.
  Quesenberry PJ, Wen S, Goldberg LR, Dooner MS. Quesenberry PJ, et al. Leukemia. 2022 Dec;36(12):2784-2792. doi: 10.1038/s41375-022-01715-w. Epub 2022 Oct 28. Leukemia. 2022. PMID: 36307485 Free PMC article. Review.
• PHF1 is required for chromosome alignment and asymmetric division during mouse meiotic oocyte maturation.
  Qu Y, Wang Y, Qiao J. Qu Y, et al. Cell Cycle. 2018;17(21-22):2447-2459. doi: 10.1080/15384101.2018.1542896. Epub 2018 Nov 11. Cell Cycle. 2018. PMID: 30382790 Free PMC article.
• Amar Klar: A giant among scientists (1947-2017).
  Singh J. Singh J. J Biosci. 2017 Sep;42(3):355-357. doi: 10.1007/s12038-017-9704-7. J Biosci. 2017. PMID: 29358548 No abstract available.
• The Endogenous GRP78 Interactome in Human Head and Neck Cancers: A Deterministic Role of Cell Surface GRP78 in Cancer Stemness.
  Chen HY, Chang JT, Chien KY, Lee YS, You GR, Cheng AJ. Chen HY, et al. Sci Rep. 2018 Jan 11;8(1):536. doi: 10.1038/s41598-017-14604-5. Sci Rep. 2018. PMID: 29323121 Free PMC article.
• A revisionist history of adult marrow stem cell biology or 'they forgot about the discard'.
  Quesenberry P, Goldberg L. Quesenberry P, et al. Leukemia. 2017 Aug;31(8):1678-1685. doi: 10.1038/leu.2017.155. Epub 2017 May 22. Leukemia. 2017. PMID: 28529310 Free PMC article. Review.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Other Literature Sources

  • The Lens - Patent Citations Database

• Medical

  • MedlinePlus Health Information