A molecular signature of metastasis in primary solid tumors - PubMed (original) (raw)
doi: 10.1038/ng1060. Epub 2002 Dec 9.
Affiliations
- PMID: 12469122
- DOI: 10.1038/ng1060
A molecular signature of metastasis in primary solid tumors
Sridhar Ramaswamy et al. Nat Genet. 2003 Jan.
Abstract
Metastasis is the principal event leading to death in individuals with cancer, yet its molecular basis is poorly understood. To explore the molecular differences between human primary tumors and metastases, we compared the gene-expression profiles of adenocarcinoma metastases of multiple tumor types to unmatched primary adenocarcinomas. We found a gene-expression signature that distinguished primary from metastatic adenocarcinomas. More notably, we found that a subset of primary tumors resembled metastatic tumors with respect to this gene-expression signature. We confirmed this finding by applying the expression signature to data on 279 primary solid tumors of diverse types. We found that solid tumors carrying the gene-expression signature were most likely to be associated with metastasis and poor clinical outcome (P < 0.03). These results suggest that the metastatic potential of human tumors is encoded in the bulk of a primary tumor, thus challenging the notion that metastases arise from rare cells within a primary tumor that have the ability to metastasize.
Comment in
- Cancer's deadly signature.
Liotta LA, Kohn EC. Liotta LA, et al. Nat Genet. 2003 Jan;33(1):10-1. doi: 10.1038/ng0103-10. Nat Genet. 2003. PMID: 12509774 No abstract available. - Genomic analysis of primary tumors does not address the prevalence of metastatic cells in the population.
Fidler IJ, Kripke ML. Fidler IJ, et al. Nat Genet. 2003 May;34(1):23; author reply 25. doi: 10.1038/ng0503-23a. Nat Genet. 2003. PMID: 12721548 No abstract available. - Genetic background is an important determinant of metastatic potential.
Hunter K, Welch DR, Liu ET. Hunter K, et al. Nat Genet. 2003 May;34(1):23-4; author reply 25. doi: 10.1038/ng0503-23b. Nat Genet. 2003. PMID: 12721549 No abstract available.
Similar articles
- Increased expression of a set of genes enriched in oxygen binding function discloses a predisposition of breast cancer bone metastases to generate metastasis spread in multiple organs.
Capulli M, Angelucci A, Driouch K, Garcia T, Clement-Lacroix P, Martella F, Ventura L, Bologna M, Flamini S, Moreschini O, Lidereau R, Ricevuto E, Muraca M, Teti A, Rucci N. Capulli M, et al. J Bone Miner Res. 2012 Nov;27(11):2387-98. doi: 10.1002/jbmr.1686. J Bone Miner Res. 2012. PMID: 22714395 - An individualized gene expression signature for prediction of lung adenocarcinoma metastases.
Qi L, Li T, Shi G, Wang J, Li X, Zhang S, Chen L, Qin Y, Gu Y, Zhao W, Guo Z. Qi L, et al. Mol Oncol. 2017 Nov;11(11):1630-1645. doi: 10.1002/1878-0261.12137. Epub 2017 Oct 10. Mol Oncol. 2017. PMID: 28922552 Free PMC article. - Unique expression patterns and alterations in the intestinal protein villin in primary and metastatic pulmonary adenocarcinomas.
Nambu Y, Iannettoni MD, Orringer MB, Beer DG. Nambu Y, et al. Mol Carcinog. 1998 Dec;23(4):234-42. Mol Carcinog. 1998. PMID: 9869452 - Molecular targets in metastasis: lessons from genomic approaches.
Fingleton B. Fingleton B. Cancer Genomics Proteomics. 2007 May-Jun;4(3):211-21. Cancer Genomics Proteomics. 2007. PMID: 17878524 Review. - The molecular signature of metastases of human hepatocellular carcinoma.
Budhu AS, Zipser B, Forgues M, Ye QH, Sun Z, Wang XW. Budhu AS, et al. Oncology. 2005;69 Suppl 1:23-7. doi: 10.1159/000086628. Epub 2005 Sep 19. Oncology. 2005. PMID: 16210873 Review.
Cited by
- Integrated microRNA and mRNA signatures associated with survival in triple negative breast cancer.
Cascione L, Gasparini P, Lovat F, Carasi S, Pulvirenti A, Ferro A, Alder H, He G, Vecchione A, Croce CM, Shapiro CL, Huebner K. Cascione L, et al. PLoS One. 2013;8(2):e55910. doi: 10.1371/journal.pone.0055910. Epub 2013 Feb 6. PLoS One. 2013. PMID: 23405235 Free PMC article. - Single-cell RNA sequencing in cancer research.
Zhang Y, Wang D, Peng M, Tang L, Ouyang J, Xiong F, Guo C, Tang Y, Zhou Y, Liao Q, Wu X, Wang H, Yu J, Li Y, Li X, Li G, Zeng Z, Tan Y, Xiong W. Zhang Y, et al. J Exp Clin Cancer Res. 2021 Mar 1;40(1):81. doi: 10.1186/s13046-021-01874-1. J Exp Clin Cancer Res. 2021. PMID: 33648534 Free PMC article. Review. - STAT3-PTTG11 abrogation inhibits proliferation and induces apoptosis in malignant glioma cells.
Cui L, Xu L, Wang G, Wen J, Luo L, Zhao H, Chen S, Zheng M, Sun C, Jin X, Yang L. Cui L, et al. Oncol Lett. 2020 Oct;20(4):6. doi: 10.3892/ol.2020.11867. Epub 2020 Jul 15. Oncol Lett. 2020. PMID: 32774480 Free PMC article. - Collaborative, Multidisciplinary Evaluation of Cancer Variants Through Virtual Molecular Tumor Boards Informs Local Clinical Practices.
Rao S, Pitel B, Wagner AH, Boca SM, McCoy M, King I, Gupta S, Park BH, Warner JL, Chen J, Rogan PK, Chakravarty D, Griffith M, Griffith OL, Madhavan S. Rao S, et al. JCO Clin Cancer Inform. 2020 Jul;4:602-613. doi: 10.1200/CCI.19.00169. JCO Clin Cancer Inform. 2020. PMID: 32644817 Free PMC article. Review. - The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.
Naba A, Clauser KR, Hoersch S, Liu H, Carr SA, Hynes RO. Naba A, et al. Mol Cell Proteomics. 2012 Apr;11(4):M111.014647. doi: 10.1074/mcp.M111.014647. Epub 2011 Dec 9. Mol Cell Proteomics. 2012. PMID: 22159717 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources