Zinc finger protein too few controls the development of monoaminergic neurons - PubMed (original) (raw)
Zinc finger protein too few controls the development of monoaminergic neurons
Gil Levkowitz et al. Nat Neurosci. 2003 Jan.
Abstract
The mechanism controlling the development of dopaminergic (DA) and serotonergic (5HT) neurons in vertebrates is not well understood. Here we characterized a zebrafish mutant--too few (tof)--that develops hindbrain 5HT and noradrenergic neurons, but does not develop hypothalamic DA and 5HT neurons. tof encodes a forebrain-specific zinc finger transcription repressor that is homologous to the mammalian Fezl (forebrain embryonic zinc finger-like protein). Mosaic and co-staining analyses showed that fezl was not expressed in DA or 5HT neurons and instead controlled development of these neurons non-cell-autonomously. Both the eh1-related repressor motif and the second zinc finger domain were necessary for tof function. Our results indicate that tof/fezl is a key component in regulating the development of monoaminergic neurons in the vertebrate brain.
Similar articles
- Neurogenin1 is a determinant of zebrafish basal forebrain dopaminergic neurons and is regulated by the conserved zinc finger protein Tof/Fezl.
Jeong JY, Einhorn Z, Mercurio S, Lee S, Lau B, Mione M, Wilson SW, Guo S. Jeong JY, et al. Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5143-8. doi: 10.1073/pnas.0600337103. Epub 2006 Mar 20. Proc Natl Acad Sci U S A. 2006. PMID: 16549779 Free PMC article. - Zinc finger gene fez-like functions in the formation of subplate neurons and thalamocortical axons.
Hirata T, Suda Y, Nakao K, Narimatsu M, Hirano T, Hibi M. Hirata T, et al. Dev Dyn. 2004 Jul;230(3):546-56. doi: 10.1002/dvdy.20068. Dev Dyn. 2004. PMID: 15188439 - The too few mutant selectively affects subgroups of monoaminergic neurons in the zebrafish forebrain.
Rink E, Guo S. Rink E, et al. Neuroscience. 2004;127(1):147-54. doi: 10.1016/j.neuroscience.2004.05.004. Neuroscience. 2004. PMID: 15219677 - Formation and patterning of the forebrain and olfactory system by zinc-finger genes Fezf1 and Fezf2.
Shimizu T, Hibi M. Shimizu T, et al. Dev Growth Differ. 2009 Apr;51(3):221-31. doi: 10.1111/j.1440-169X.2009.01088.x. Epub 2009 Feb 16. Dev Growth Differ. 2009. PMID: 19222525 Review. - Brain monoaminergic neurons and ventilatory control in vertebrates.
Gargaglioni LH, Bícegoa KC, Branco LG. Gargaglioni LH, et al. Respir Physiol Neurobiol. 2008 Dec 10;164(1-2):112-22. doi: 10.1016/j.resp.2008.04.017. Respir Physiol Neurobiol. 2008. PMID: 18550453 Review.
Cited by
- A systematic approach to identify functional motifs within vertebrate developmental enhancers.
Li Q, Ritter D, Yang N, Dong Z, Li H, Chuang JH, Guo S. Li Q, et al. Dev Biol. 2010 Jan 15;337(2):484-95. doi: 10.1016/j.ydbio.2009.10.019. Epub 2009 Oct 20. Dev Biol. 2010. PMID: 19850031 Free PMC article. - Gonadotropin Releasing Hormone (Gnrh) Triggers Neurogenesis in the Hypothalamus of Adult Zebrafish.
Ceriani R, Whitlock KE. Ceriani R, et al. Int J Mol Sci. 2021 May 31;22(11):5926. doi: 10.3390/ijms22115926. Int J Mol Sci. 2021. PMID: 34072957 Free PMC article. - fezf2 expression delineates cells with proliferative potential and expressing markers of neural stem cells in the adult zebrafish brain.
Berberoglu MA, Dong Z, Mueller T, Guo S. Berberoglu MA, et al. Gene Expr Patterns. 2009 Sep;9(6):411-22. doi: 10.1016/j.gep.2009.06.002. Epub 2009 Jun 12. Gene Expr Patterns. 2009. PMID: 19524703 Free PMC article. - Molecular psychiatry of zebrafish.
Stewart AM, Ullmann JF, Norton WH, Parker MO, Brennan CH, Gerlai R, Kalueff AV. Stewart AM, et al. Mol Psychiatry. 2015 Feb;20(1):2-17. doi: 10.1038/mp.2014.128. Epub 2014 Oct 28. Mol Psychiatry. 2015. PMID: 25349164 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Molecular Biology Databases
Miscellaneous