Natural product guided compound library development - PubMed (original) (raw)
Review
. 2002 Dec;9(23):2129-45.
doi: 10.2174/0929867023368773.
Affiliations
- PMID: 12470251
- DOI: 10.2174/0929867023368773
Review
Natural product guided compound library development
Rolf Breinbauer et al. Curr Med Chem. 2002 Dec.
Abstract
Natural products are biologically validated starting points for the design of combinatorial libraries, as they have a proven record of biological relevance. This special role of natural products in medicinal chemistry and chemical biology can be interpreted in the light of new insights about the domain architecture of proteins gained by structural biology and bioinformatics. In order to fulfil the specific requirements of the individual binding pocket within a domain family it is necessary to optimise the natural product structure by chemical variation. Solid-phase chemistry is becoming an efficient tool for this optimisation process, and recent advances in this field are highlighted in this review article.
Similar articles
- Advancing chemistry and biology through diversity-oriented synthesis of natural product-like libraries.
Shang S, Tan DS. Shang S, et al. Curr Opin Chem Biol. 2005 Jun;9(3):248-58. doi: 10.1016/j.cbpa.2005.03.006. Curr Opin Chem Biol. 2005. PMID: 15939326 Review. - From protein domains to drug candidates-natural products as guiding principles in the design and synthesis of compound libraries.
Breinbauer R, Vetter IR, Waldmann H. Breinbauer R, et al. Angew Chem Int Ed Engl. 2002 Aug 16;41(16):2879-90. doi: 10.1002/1521-3773(20020816)41:16<2878::AID-ANIE2878>3.0.CO;2-B. Angew Chem Int Ed Engl. 2002. PMID: 12203413 Review. - Protein structure similarity clustering and natural product structure as guiding principles in drug discovery.
Koch MA, Waldmann H. Koch MA, et al. Drug Discov Today. 2005 Apr 1;10(7):471-83. doi: 10.1016/S1359-6446(05)03419-7. Drug Discov Today. 2005. PMID: 15809193 Review. - Synthesis of natural-product-based compound libraries.
Wessjohann LA. Wessjohann LA. Curr Opin Chem Biol. 2000 Jun;4(3):303-9. doi: 10.1016/s1367-5931(00)00093-4. Curr Opin Chem Biol. 2000. PMID: 10826981 Review. - Current progress in natural product-like libraries for discovery screening.
Tan DS. Tan DS. Comb Chem High Throughput Screen. 2004 Nov;7(7):631-43. doi: 10.2174/1386207043328418. Comb Chem High Throughput Screen. 2004. PMID: 15578925 Review.
Cited by
- Do we need new antibiotics? The search for new targets and new compounds.
Spížek J, Novotná J, Rezanka T, Demain AL. Spížek J, et al. J Ind Microbiol Biotechnol. 2010 Dec;37(12):1241-8. doi: 10.1007/s10295-010-0849-8. Epub 2010 Nov 18. J Ind Microbiol Biotechnol. 2010. PMID: 21086099 - Neurobiological applications of small molecule screening.
Bauer A, Stockwell B. Bauer A, et al. Chem Rev. 2008 May;108(5):1774-86. doi: 10.1021/cr0782372. Epub 2008 May 1. Chem Rev. 2008. PMID: 18447397 Free PMC article. Review. No abstract available. - Natural products as sources of new drugs over the 30 years from 1981 to 2010.
Newman DJ, Cragg GM. Newman DJ, et al. J Nat Prod. 2012 Mar 23;75(3):311-35. doi: 10.1021/np200906s. Epub 2012 Feb 8. J Nat Prod. 2012. PMID: 22316239 Free PMC article. Review. - Synthesis of tetrahydrohonokiol derivates and their evaluation for cytotoxic activity against CCRF-CEM leukemia, U251 glioblastoma and HCT-116 colon cancer cells.
Bernaskova M, Kretschmer N, Schuehly W, Huefner A, Weis R, Bauer R. Bernaskova M, et al. Molecules. 2014 Jan 20;19(1):1223-37. doi: 10.3390/molecules19011223. Molecules. 2014. PMID: 24448063 Free PMC article. - Importance of microbial natural products and the need to revitalize their discovery.
Demain AL. Demain AL. J Ind Microbiol Biotechnol. 2014 Feb;41(2):185-201. doi: 10.1007/s10295-013-1325-z. Epub 2013 Aug 30. J Ind Microbiol Biotechnol. 2014. PMID: 23990168 Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources