Porphyromonas gingivalis, Bacteroides forsythus and other putative periodontal pathogens in subjects with and without periodontal destruction - PubMed (original) (raw)
Comparative Study
Porphyromonas gingivalis, Bacteroides forsythus and other putative periodontal pathogens in subjects with and without periodontal destruction
A J van Winkelhoff et al. J Clin Periodontol. 2002 Nov.
Abstract
Background and aims: Bacteria play an essential role in the pathogenesis of destructive periodontal disease. It has been suggested that not all bacteria associated with periodontitis may be normal inhabitants of a periodontally healthy dentition. In particular, Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans have been isolated infrequently from subjects without periodontitis. The aim of the present study was to compare prevalence and proportions of a number of periodontal bacteria in periodontitis patients and control subjects.
Material and methods: In all, 116 consecutive subjects diagnosed with moderate to severe periodontitis (mean age 42.4) and 94 subjects without radiographic evidence of alveolar bone loss (mean age 40.4) were recruited for the study. The gingival condition in the control group varied between gingival health and various degrees of gingivitis. In patients, the deepest pocket in each quadrant was selected for microbiological sampling. In control subjects all mesial and distal sites of all first molars were selected for sampling. All paper points from a patient were pooled and processed for anaerobic cultivation within 6 h after sampling. Clinical variables of sampled sites included bleeding index, probing pocket depth and clinical attachment level.
Results: A. actinomycetemcomitans, P. gingivalis, Prevotella intermedia, Bacteroides forsythus, Fusobacterium nucleatum and Peptostreptococcus micros were significantly more often prevalent in patients than in controls. The highest odds ratios were found for P. gingivalis and B. forsythus (12.3 and 10.4 resp.). Other odds ratios varied from 3.1 to 7.7 for A. actinomycetemcomitans and P. micros, respectively. Absolute numbers of target bacteria were all higher in patients, but only the mean percentage of B. forsythus was significantly higher in patients in comparison to controls (P < 0.001).
Conclusions: A. actinomycetemcomitans, P. gingivalis, P. intermedia, B. forsythus, F. nucleatum and P. micros are all significant markers for destructive periodontal disease in adult subjects. Based on calculated odds ratios, B. forsythus and P. gingivalis are the strongest bacterial markers for this disease and are infrequently cultured from subjects without periodontal bone loss.
Similar articles
- Smoking affects the subgingival microflora in periodontitis.
van Winkelhoff AJ, Bosch-Tijhof CJ, Winkel EG, van der Reijden WA. van Winkelhoff AJ, et al. J Periodontol. 2001 May;72(5):666-71. doi: 10.1902/jop.2001.72.5.666. J Periodontol. 2001. PMID: 11394403 - Salivary infectious agents and periodontal disease status.
Saygun I, Nizam N, Keskiner I, Bal V, Kubar A, Açıkel C, Serdar M, Slots J. Saygun I, et al. J Periodontal Res. 2011 Apr;46(2):235-9. doi: 10.1111/j.1600-0765.2010.01335.x. Epub 2011 Jan 25. J Periodontal Res. 2011. PMID: 21261620 - Prevalence of 6 putative periodontal pathogens in subgingival plaque samples from Romanian adult periodontitis patients.
Ali RW, Velcescu C, Jivanescu MC, Lofthus B, Skaug N. Ali RW, et al. J Clin Periodontol. 1996 Feb;23(2):133-9. doi: 10.1111/j.1600-051x.1996.tb00546.x. J Clin Periodontol. 1996. PMID: 8849850 - Can presence or absence of periodontal pathogens distinguish between subjects with chronic and aggressive periodontitis? A systematic review.
Mombelli A, Casagni F, Madianos PN. Mombelli A, et al. J Clin Periodontol. 2002;29 Suppl 3:10-21; discussion 37-8. doi: 10.1034/j.1600-051x.29.s3.1.x. J Clin Periodontol. 2002. PMID: 12787203 Review. - An update on possible alternative therapeutics for future periodontal disease management.
Das V, Vinod V, Biswas L, Kumar A, Biswas R. Das V, et al. J Appl Microbiol. 2023 Jan 23;134(1):lxac039. doi: 10.1093/jambio/lxac039. J Appl Microbiol. 2023. PMID: 36724261 Review.
Cited by
- Optimization of quantitative polymerase chain reactions for detection and quantification of eight periodontal bacterial pathogens.
Decat E, Cosyn J, De Bruyn H, Miremadi R, Saerens B, Van Mechelen E, Vermeulen S, Vaneechoutte M, Deschaght P. Decat E, et al. BMC Res Notes. 2012 Dec 2;5:664. doi: 10.1186/1756-0500-5-664. BMC Res Notes. 2012. PMID: 23199017 Free PMC article. - Effect of periodontal treatment on glycemic control of diabetic patients: a systematic review and meta-analysis.
Teeuw WJ, Gerdes VE, Loos BG. Teeuw WJ, et al. Diabetes Care. 2010 Feb;33(2):421-7. doi: 10.2337/dc09-1378. Diabetes Care. 2010. PMID: 20103557 Free PMC article. Review. - A Placebo-Controlled Trial to Evaluate Two Locally Delivered Antibiotic Gels (Piperacillin Plus Tazobactam vs. Doxycycline) in Stage III-IV Periodontitis Patients.
Ilyes I, Rusu D, Rădulescu V, Vela O, Boariu MI, Roman A, Surlin P, Kardaras G, Boia S, Chinnici S, Jentsch HFR, Stratul SI. Ilyes I, et al. Medicina (Kaunas). 2023 Feb 7;59(2):303. doi: 10.3390/medicina59020303. Medicina (Kaunas). 2023. PMID: 36837504 Free PMC article. Clinical Trial. - Putative periodontopathic bacteria and herpes viruses interactions in the subgingival plaque of patients with aggressive periodontitis and healthy controls.
Elamin A, Ali RW, Bakken V. Elamin A, et al. Clin Exp Dent Res. 2017 Oct 27;3(5):183-190. doi: 10.1002/cre2.80. eCollection 2017 Oct. Clin Exp Dent Res. 2017. PMID: 29744199 Free PMC article. - Inhibitory effect of Lactobacillus reuteri on periodontopathic and cariogenic bacteria.
Kang MS, Oh JS, Lee HC, Lim HS, Lee SW, Yang KH, Choi NK, Kim SM. Kang MS, et al. J Microbiol. 2011 Apr;49(2):193-9. doi: 10.1007/s12275-011-0252-9. Epub 2011 May 3. J Microbiol. 2011. PMID: 21538238
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources