Physical training increases eNOS vascular expression and activity and reduces restenosis after balloon angioplasty or arterial stenting in rats - PubMed (original) (raw)

Physical training increases eNOS vascular expression and activity and reduces restenosis after balloon angioplasty or arterial stenting in rats

Ciro Indolfi et al. Circ Res. 2002.

Abstract

The effects of dynamic exercise on restenosis after vascular injury are still unknown. The consequences of balloon dilation-induced injury on neointimal hyperplasia, vascular negative remodeling, and reendothelialization were assessed in sedentary and trained rats. Ex vivo eNOS vascular expression and activity were investigated in carotid arteries isolated from sedentary and exercised rats. The in vivo effects of eNOS inhibition by L-NMMA on vessel wall after balloon dilation were evaluated in sedentary and exercised rats. We also investigated the effects of exercise on neointimal formation in a rat stent model of vascular injury. Compared with sedentary group, the arteries isolated from trained rats showed higher levels of eNOS protein expression and activity 7 days after balloon dilation. A significant reduction of both neointimal hyperplasia and negative remodeling was observed 14 days after balloon injury in trained compared with sedentary rats. Moreover, we demonstrated that exercise training produced accelerated reendothelialization of the balloon injured arterial segments compared with sedentary. L-NMMA administration eliminated the benefits of physical training on vessel wall after balloon dilation. Finally, a decrease of neointimal hyperplasia as well as of platelet aggregation was observed after stent deployment in trained rats compared with sedentary. In conclusion, physical exercise could favorably affect restenosis after balloon angioplasty and stenting. Increase in eNOS expression and activity might contribute to the potential beneficial effects of exercise on the vessel wall after vascular injury.

PubMed Disclaimer

Comment in

Physical training and restenosis.
Ward M. Ward M. Circ Res. 2003 Apr 4;92(6):e60; author reply e60. doi: 10.1161/01.RES.0000067466.48892.EC. Circ Res. 2003. PMID: 12676812 No abstract available.

Cited by

Effects of endothelium, stent design and deployment on the nitric oxide transport in stented artery: a potential role in stent restenosis and thrombosis.
Liu X, Wang M, Zhang N, Fan Z, Fan Y, Deng X. Liu X, et al. Med Biol Eng Comput. 2015 May;53(5):427-39. doi: 10.1007/s11517-015-1250-6. Epub 2015 Feb 26. Med Biol Eng Comput. 2015. PMID: 25715753
Sophocarpine Alleviates Injury-Induced Intima Hyperplasia of Carotid Arteries by Suppressing Inflammation in a Rat Model.
Yang G, Zeng R, Song X, Liu C, Ni L. Yang G, et al. J Clin Med. 2021 Nov 22;10(22):5449. doi: 10.3390/jcm10225449. J Clin Med. 2021. PMID: 34830730 Free PMC article.
Low-fat diet and exercise preserve eNOS regulation and endothelial function in the penis of early atherosclerotic pigs: a molecular analysis.
Musicki B, Liu T, Strong T, Jin L, Laughlin MH, Turk JR, Burnett AL. Musicki B, et al. J Sex Med. 2008 Mar;5(3):552-61. doi: 10.1111/j.1743-6109.2007.00731.x. Epub 2008 Jan 10. J Sex Med. 2008. PMID: 18194184 Free PMC article.
Roles of MicroRNAs in Peripheral Artery In-Stent Restenosis after Endovascular Treatment.
Wang M, Zhang W, Zhang L, Wang L, Li J, Shu C, Li X. Wang M, et al. Biomed Res Int. 2021 Jul 27;2021:9935671. doi: 10.1155/2021/9935671. eCollection 2021. Biomed Res Int. 2021. PMID: 34368362 Free PMC article. Review.
The effects of stenting on coronary endothelium from a molecular biological view: Time for improvement?
Cornelissen A, Vogt FJ. Cornelissen A, et al. J Cell Mol Med. 2019 Jan;23(1):39-46. doi: 10.1111/jcmm.13936. Epub 2018 Oct 23. J Cell Mol Med. 2019. PMID: 30353645 Free PMC article. Review.

Physical training increases eNOS vascular expression and activity and reduces restenosis after balloon angioplasty or arterial stenting in rats - PubMed (original) (raw)