Anti-hyperlipidemic sesquiterpenes and new sesquiterpene glycosides from the leaves of artichoke (Cynara scolymus L.): structure requirement and mode of action - PubMed (original) (raw)
Anti-hyperlipidemic sesquiterpenes and new sesquiterpene glycosides from the leaves of artichoke (Cynara scolymus L.): structure requirement and mode of action
Hiroshi Shimoda et al. Bioorg Med Chem Lett. 2003.
Abstract
The methanolic extract from the leaves of artichoke (Cynara scolymus L.) was found to suppress serum triglyceride elevation in olive oil-loaded mice. Through bioassay-guided separation, sesquiterpenes (cynaropicrin, aguerin B, and grosheimin) were isolated as the active components together with new sesquiterpene glycosides (cynarascolosides A, B, and C). The oxygen functional groups at the 3- and 8-positions and exo-methylene moiety in alpha-methylene-gamma-butyrolactone ring were found to be essential for the anti-hyperlipidemic activity of guaiane-type sesquiterpene. In addition, inhibition of gastric emptying was shown to be partly involved in anti-hyperlipidemic activity.
Similar articles
- Inhibitory effects of cynaropicrin and related sesquiterpene lactones from leaves of artichoke (Cynara scolymus L.) on induction of iNOS in RAW264.7 cells and its high-affinity proteins.
Matsumoto T, Nakashima S, Nakamura S, Hattori Y, Ando T, Matsuda H. Matsumoto T, et al. J Nat Med. 2021 Mar;75(2):381-392. doi: 10.1007/s11418-020-01479-6. Epub 2021 Jan 23. J Nat Med. 2021. PMID: 33484417 - Chemical constituents and anti-ulcerogenic potential of the scales of Cynara scolymus (artichoke) heads.
Nassar MI, Mohamed TK, Elshamy AI, El-Toumy SA, Abdel Lateef AM, Farrag AR. Nassar MI, et al. J Sci Food Agric. 2013 Aug 15;93(10):2494-501. doi: 10.1002/jsfa.6065. Epub 2013 Apr 9. J Sci Food Agric. 2013. PMID: 23576039 - The Joint Action of Sesquiterpene Lactones from Leaves as an Explanation for the Activity of Cynara cardunculus.
Rial C, García BF, Varela RM, Torres A, Molinillo JM, Macías FA. Rial C, et al. J Agric Food Chem. 2016 Aug 24;64(33):6416-24. doi: 10.1021/acs.jafc.6b02678. Epub 2016 Aug 10. J Agric Food Chem. 2016. PMID: 27487046 - Subcellular distribution of enzymes of mono- and sesquiterpene biosynthesis in plant tissues.
Pérez LM. Pérez LM. Arch Biol Med Exp. 1988 Jun;21(1):51-8. Arch Biol Med Exp. 1988. PMID: 3154867 Review. - Cynaropicrin: A Comprehensive Research Review and Therapeutic Potential As an Anti-Hepatitis C Virus Agent.
Elsebai MF, Mocan A, Atanasov AG. Elsebai MF, et al. Front Pharmacol. 2016 Dec 8;7:472. doi: 10.3389/fphar.2016.00472. eCollection 2016. Front Pharmacol. 2016. PMID: 28008316 Free PMC article. Review.
Cited by
- Globe Artichoke (Cynara scolymus L.) By-Products in Food Applications: Functional and Biological Properties.
Colombo R, Moretto G, Pellicorio V, Papetti A. Colombo R, et al. Foods. 2024 May 7;13(10):1427. doi: 10.3390/foods13101427. Foods. 2024. PMID: 38790727 Free PMC article. Review. - Ameliorative effect of bofutsushosan (Fangfengtongshengsan) extract on the progression of aging-induced obesity.
Saeki T, Yamamoto S, Akaki J, Tanaka T, Nakasone M, Ikeda H, Wang W, Inoue M, Manse Y, Ninomiya K, Morikawa T. Saeki T, et al. J Nat Med. 2024 Jun;78(3):576-589. doi: 10.1007/s11418-024-01803-4. Epub 2024 Apr 25. J Nat Med. 2024. PMID: 38662301 - Functional and Therapeutic Potential of Cynara scolymus in Health Benefits.
Porro C, Benameur T, Cianciulli A, Vacca M, Chiarini M, De Angelis M, Panaro MA. Porro C, et al. Nutrients. 2024 Mar 17;16(6):872. doi: 10.3390/nu16060872. Nutrients. 2024. PMID: 38542782 Free PMC article. Review. - An Overview of the Versatility of the Parts of the Globe Artichoke (Cynara scolymus L.), Its By-Products and Dietary Supplements.
Olas B. Olas B. Nutrients. 2024 Feb 22;16(5):599. doi: 10.3390/nu16050599. Nutrients. 2024. PMID: 38474726 Free PMC article. Review. - Aromatase inhibitors isolated from a flowering tea, snow Chrysanthemum (the capitula of Coreopsis tinctoria Nutt.).
Luo F, Manse Y, Ishikawa S, Nishi S, Chen A, Wang T, Morikawa T. Luo F, et al. J Nat Med. 2023 Mar;77(2):387-396. doi: 10.1007/s11418-022-01678-3. Epub 2023 Jan 11. J Nat Med. 2023. PMID: 36630026
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical