Diagnosis of Legionella infection - PubMed (original) (raw)
doi: 10.1086/345529. Epub 2002 Dec 12.
Affiliations
- PMID: 12491204
- DOI: 10.1086/345529
Diagnosis of Legionella infection
David R Murdoch. Clin Infect Dis. 2003.
Abstract
Legionellae, which are important causes of pneumonia in humans, continue to be incorrectly labeled as exotic pathogens. The ability to diagnose Legionella infection is limited by the nonspecific nature of clinical features and the shortcomings of diagnostic tests. Despite recent improvements, existing diagnostic tests for Legionella infection either lack sensitivity for detecting all clinically important legionellae or are unable to provide results within a clinically useful time frame. Understanding local Legionella epidemiology is important for making decisions about whether to test for Legionella infection and which diagnostic tests to use. In most situations, the use of both the urinary antigen test plus sputum culture is the best diagnostic combination. Polymerase chain reaction (PCR) is a promising tool, but standardized assays are not commercially available. Further work needs to focus on the development of urinary antigen tests assays that detect a wider range of pathogenic legionellae and on the development of standardized PCR assays.
Similar articles
- Rapid tests for the diagnosis of Legionella infections.
Ramirez JA, Summersgill JT. Ramirez JA, et al. J Ky Med Assoc. 1994 Feb;92(2):62-5. J Ky Med Assoc. 1994. PMID: 8163902 - [Microbiological diagnosis of respiratory infections caused by Legionella pneumophila].
Rokosz N, Rastawicki W, Zasada AA, Baczewska-Rej M. Rokosz N, et al. Pneumonol Alergol Pol. 2010;78(1):54-9. Pneumonol Alergol Pol. 2010. PMID: 20162519 Polish. - [Immunologic tests: Legionella spp].
Higashiyama Y, Kohno S. Higashiyama Y, et al. Nihon Rinsho. 2005 Jul;63 Suppl 7:184-6. Nihon Rinsho. 2005. PMID: 16111222 Review. Japanese. No abstract available. - Overview of diagnostic and detection methods for legionellosis and Legionella spp.
Tronel H, Hartemann P. Tronel H, et al. Lett Appl Microbiol. 2009 Jun;48(6):653-6. doi: 10.1111/j.1472-765X.2009.02570.x. Epub 2009 Mar 7. Lett Appl Microbiol. 2009. PMID: 19291209 Review. - Evaluation of the SAS Legionella Test, a new immunochromatographic assay for the detection of Legionella pneumophila serogroup 1 antigen in urine.
Diederen BM, Peeters MF. Diederen BM, et al. Clin Microbiol Infect. 2007 Jan;13(1):86-8. doi: 10.1111/j.1469-0691.2006.01587.x. Clin Microbiol Infect. 2007. PMID: 17184292
Cited by
- High performance Legionella pneumophila source attribution using genomics-based machine learning classification.
Buultjens AH, Vandelannoote K, Mercoulia K, Ballard S, Sloggett C, Howden BP, Seemann T, Stinear TP. Buultjens AH, et al. Appl Environ Microbiol. 2024 Mar 20;90(3):e0129223. doi: 10.1128/aem.01292-23. Epub 2024 Jan 30. Appl Environ Microbiol. 2024. PMID: 38289130 Free PMC article. - Hairy Cell Leukemia (HCL) Presenting As Severe Acute Respiratory Distress Syndrome (ARDS) With Legionella pneumophila: Coincidence or Causation?
Holloway KD, Amisha F, Post G, Goraya H. Holloway KD, et al. Cureus. 2023 Nov 5;15(11):e48317. doi: 10.7759/cureus.48317. eCollection 2023 Nov. Cureus. 2023. PMID: 38058334 Free PMC article. - Therapeutical strategies in cavitary legionnaires' disease, two cases from the field and a systematic review.
Moretti M, De Boek L, Ilsen B, Demuyser T, Vanderhelst E. Moretti M, et al. Ann Clin Microbiol Antimicrob. 2023 Nov 29;22(1):105. doi: 10.1186/s12941-023-00652-5. Ann Clin Microbiol Antimicrob. 2023. PMID: 38031167 Free PMC article. Review. - Legionellosis on the rise: A scoping review of sporadic, community-acquired incidence in the United States.
Moffa MA, Rock C, Galiatsatos P, Gamage SD, Schwab KJ, Exum NG. Moffa MA, et al. Epidemiol Infect. 2023 Jul 28;151:e133. doi: 10.1017/S0950268823001206. Epidemiol Infect. 2023. PMID: 37503568 Free PMC article. Review. - Clinical and Laboratory Diagnosis of Legionella Pneumonia.
Bai L, Yang W, Li Y. Bai L, et al. Diagnostics (Basel). 2023 Jan 12;13(2):280. doi: 10.3390/diagnostics13020280. Diagnostics (Basel). 2023. PMID: 36673091 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical