Genetic structure of human populations - PubMed (original) (raw)

. 2002 Dec 20;298(5602):2381-5.

doi: 10.1126/science.1078311.

Affiliations

• PMID: 12493913
• DOI: 10.1126/science.1078311

Genetic structure of human populations

Noah A Rosenberg et al. Science. 2002.

Abstract

We studied human population structure using genotypes at 377 autosomal microsatellite loci in 1056 individuals from 52 populations. Within-population differences among individuals account for 93 to 95% of genetic variation; differences among major groups constitute only 3 to 5%. Nevertheless, without using prior information about the origins of individuals, we identified six main genetic clusters, five of which correspond to major geographic regions, and subclusters that often correspond to individual populations. General agreement of genetic and predefined populations suggests that self-reported ancestry can facilitate assessments of epidemiological risks but does not obviate the need to use genetic information in genetic association studies.

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Comment in

• Human genetics. Mapping human history.
  King MC, Motulsky AG. King MC, et al. Science. 2002 Dec 20;298(5602):2342-3. doi: 10.1126/science.1080373. Science. 2002. PMID: 12493903 No abstract available.
• Ethnic differences and disease phenotypes.
  Hardy J, Singleton A, Gwinn-Hardy K. Hardy J, et al. Science. 2003 May 2;300(5620):739-40. doi: 10.1126/science.300.5620.739. Science. 2003. PMID: 12730580 No abstract available.
• Comment on "Genetic structure of human populations".
  Excoffier L, Hamilton G. Excoffier L, et al. Science. 2003 Jun 20;300(5627):1877; author reply 1877. doi: 10.1126/science.1083411. Science. 2003. PMID: 12817127 No abstract available.

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