Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol - PubMed (original) (raw)
Clinical Trial
Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol
Robert P Heaney et al. Am J Clin Nutr. 2003 Jan.
Erratum in
- Am J Clin Nutr. 2003 Nov;78(5):1047
Abstract
Background: The cholecalciferol inputs required to achieve or maintain any given serum 25-hydroxycholecalciferol concentration are not known, particularly within ranges comparable to the probable physiologic supply of the vitamin.
Objectives: The objectives were to establish the quantitative relation between steady state cholecalciferol input and the resulting serum 25-hydroxycholecalciferol concentration and to estimate the proportion of the daily requirement during winter that is met by cholecalciferol reserves in body tissue stores.
Design: Cholecalciferol was administered daily in controlled oral doses labeled at 0, 25, 125, and 250 micro g cholecalciferol for approximately 20 wk during the winter to 67 men living in Omaha (41.2 degrees N latitude). The time course of serum 25-hydroxycholecalciferol concentration was measured at intervals over the course of treatment.
Results: From a mean baseline value of 70.3 nmol/L, equilibrium concentrations of serum 25-hydroxycholecalciferol changed during the winter months in direct proportion to the dose, with a slope of approximately 0.70 nmol/L for each additional 1 micro g cholecalciferol input. The calculated oral input required to sustain the serum 25-hydroxycholecalciferol concentration present before the study (ie, in the autumn) was 12.5 micro g (500 IU)/d, whereas the total amount from all sources (supplement, food, tissue stores) needed to sustain the starting 25-hydroxycholecalciferol concentration was estimated at approximately 96 micro g (approximately 3800 IU)/d. By difference, the tissue stores provided approximately 78-82 micro g/d.
Conclusions: Healthy men seem to use 3000-5000 IU cholecalciferol/d, apparently meeting > 80% of their winter cholecalciferol need with cutaneously synthesized accumulations from solar sources during the preceding summer months. Current recommended vitamin D inputs are inadequate to maintain serum 25-hydroxycholecalciferol concentration in the absence of substantial cutaneous production of vitamin D.
Comment in
- Serum 25-hydroxyvitamin D response to oral vitamin D intake in children.
Zittermann A. Zittermann A. Am J Clin Nutr. 2003 Sep;78(3):496-7. doi: 10.1093/ajcn/78.3.496. Am J Clin Nutr. 2003. PMID: 12936937 Clinical Trial. No abstract available.
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