Transcriptional activators stimulate DNA repair - PubMed (original) (raw)
Transcriptional activators stimulate DNA repair
Philippe Frit et al. Mol Cell. 2002 Dec.
Free article
Abstract
To counteract the deleterious effects of genotoxic injury, cells have set up a sophisticated network of DNA repair pathways. We show that Gal4-VP16 and RAR transcriptional activators stimulate nucleotide excision repair (NER). This DNA repair activation is not coupled to transcription since it occurs in Cockayne syndrome cells (which are transcription-coupled repair deficient) and is observed in vitro in the presence of alpha-amanitin and in the absence of the basal transcription factors. Using a reconstituted dual incision assay, we also show that binding of activators to their cognate sequences induces a local chromatin remodeling mediated by ATP-driven chromatin remodeling and acetyltransferase activities to facilitate DNA repair.
Similar articles
- Biochemical mechanism of transcriptional activation by GAL4-VP16.
Tantin D, Chi T, Hori R, Pyo S, Carey M. Tantin D, et al. Methods Enzymol. 1996;274:133-49. doi: 10.1016/s0076-6879(96)74013-2. Methods Enzymol. 1996. PMID: 8902801 No abstract available. - Synergism between Tat and VP16 in trans-activation of HIV-1 LTR.
Ghosh S, Selby MJ, Peterlin BM. Ghosh S, et al. J Mol Biol. 1993 Dec 5;234(3):610-9. doi: 10.1006/jmbi.1993.1615. J Mol Biol. 1993. PMID: 8254663 - HMG17 is a chromatin-specific transcriptional coactivator that increases the efficiency of transcription initiation.
Paranjape SM, Krumm A, Kadonaga JT. Paranjape SM, et al. Genes Dev. 1995 Aug 15;9(16):1978-91. doi: 10.1101/gad.9.16.1978. Genes Dev. 1995. PMID: 7649479 - Mechanisms of viral activators.
Berk AJ, Boyer TG, Kapanidis AN, Ebright RH, Kobayashi NN, Horn PJ, Sullivan SM, Koop R, Surby MA, Triezenberg SJ. Berk AJ, et al. Cold Spring Harb Symp Quant Biol. 1998;63:243-52. doi: 10.1101/sqb.1998.63.243. Cold Spring Harb Symp Quant Biol. 1998. PMID: 10384288 Review. - Structure and functions of powerful transactivators: VP16, MyoD and FoxA.
Hirai H, Tani T, Kikyo N. Hirai H, et al. Int J Dev Biol. 2010;54(11-12):1589-96. doi: 10.1387/ijdb.103194hh. Int J Dev Biol. 2010. PMID: 21404180 Free PMC article. Review.
Cited by
- Zinc finger transcription factor CASZ1b is involved in the DNA damage response in live cells.
Liu Z, Kruhlak MJ, Thiele CJ. Liu Z, et al. Biochem Biophys Res Commun. 2023 Jun 30;663:171-178. doi: 10.1016/j.bbrc.2023.04.085. Epub 2023 Apr 25. Biochem Biophys Res Commun. 2023. PMID: 37121127 Free PMC article. - Beyond the Trinity of ATM, ATR, and DNA-PK: Multiple Kinases Shape the DNA Damage Response in Concert With RNA Metabolism.
Burger K, Ketley RF, Gullerova M. Burger K, et al. Front Mol Biosci. 2019 Aug 2;6:61. doi: 10.3389/fmolb.2019.00061. eCollection 2019. Front Mol Biosci. 2019. PMID: 31428617 Free PMC article. Review. - At the Interface of Three Nucleic Acids: The Role of RNA-Binding Proteins and Poly(ADP-ribose) in DNA Repair.
Alemasova EE, Lavrik OI. Alemasova EE, et al. Acta Naturae. 2017 Apr-Jun;9(2):4-16. Acta Naturae. 2017. PMID: 28740723 Free PMC article. - Rad9 interacts with Aft1 to facilitate genome surveillance in fragile genomic sites under non-DNA damage-inducing conditions in S. cerevisiae.
Andreadis C, Nikolaou C, Fragiadakis GS, Tsiliki G, Alexandraki D. Andreadis C, et al. Nucleic Acids Res. 2014 Nov 10;42(20):12650-67. doi: 10.1093/nar/gku915. Epub 2014 Oct 9. Nucleic Acids Res. 2014. PMID: 25300486 Free PMC article. - DNA damage-activated ABL-MyoD signaling contributes to DNA repair in skeletal myoblasts.
Simonatto M, Marullo F, Chiacchiera F, Musaró A, Wang JY, Latella L, Puri PL. Simonatto M, et al. Cell Death Differ. 2013 Dec;20(12):1664-74. doi: 10.1038/cdd.2013.118. Epub 2013 Sep 20. Cell Death Differ. 2013. PMID: 24056763 Free PMC article.