Immunisation of metastatic cancer patients with MAGE-3 protein combined with adjuvant SBAS-2: a clinical report - PubMed (original) (raw)

Clinical Trial

doi: 10.1016/s0959-8049(02)00479-3.

C J A Punt, S Aamdal, B Escudier, W H J Kruit, U Keilholz, L Håkansson, N van Baren, Y Humblet, P Mulders, M-F Avril, A M M Eggermont, C Scheibenbogen, J Uiters, J Wanders, M Delire, T Boon, G Stoter

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Clinical Trial

Immunisation of metastatic cancer patients with MAGE-3 protein combined with adjuvant SBAS-2: a clinical report

M Marchand et al. Eur J Cancer. 2003 Jan.

Abstract

Fifty-seven patients with MAGE-3-positive measurable metastatic cancer, most of them with melanoma, were vaccinated with escalating doses of a recombinant MAGE-3 protein combined with a fixed dose of the immunological adjuvant SBAS-2, which contained MPL and QS21. The immunisation schedule included 4 intramuscular (i.m.) injections at 3-week intervals. Patients whose tumour stabilised or regressed after 4 vaccinations received 2 additional vaccinations at 6-week intervals. The vaccine was generally well tolerated. Among the 33 melanoma patients who were evaluable for tumour response, we observed 2 partial responses, 2 mixed responses and 1 stabilisation. Time to progression in these 5 patients varied from 4 to 29 months. In addition, a partial response lasting 10 months was observed in 1 of the 3 metastatic bladder cancer patients included. None of the tumour responses described above involved visceral metastases. Immunological responses to the vaccine will be reported separately.

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