Metastasis suppressors alter the signal transduction of cancer cells - PubMed (original) (raw)

Review

doi: 10.1038/nrc967.

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• PMID: 12509767
• DOI: 10.1038/nrc967

Review

Metastasis suppressors alter the signal transduction of cancer cells

Patricia S Steeg. Nat Rev Cancer. 2003 Jan.

Abstract

Tumour metastasis is a significant contributor to death in cancer patients. Eight metastasis-suppressor genes that reduce the metastatic propensity of a cancer cell line in vivo without affecting its tumorigenicity have been identified. These affect important signal-transduction pathways, including mitogen-activated protein kinases, RHO, RAC and G-protein-coupled and tyrosine-kinase receptors. So how might we use this knowledge to improve the treatment of patients with cancer?

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