Thymopoiesis independent of common lymphoid progenitors - PubMed (original) (raw)
Comparative Study
doi: 10.1038/ni878. Epub 2003 Jan 6.
Affiliations
- PMID: 12514733
- DOI: 10.1038/ni878
Comparative Study
Thymopoiesis independent of common lymphoid progenitors
David Allman et al. Nat Immunol. 2003 Feb.
Abstract
Early T lineage progenitors (ETPs) in the thymus are thought to develop from common lymphoid progenitors (CLPs) in the bone marrow (BM). We compared thymic ETPs to BM CLPs in mice and found that they differed in several respects. Thymic ETPs were not interleukin 7 (IL-7)-responsive and generated B lineage progeny with delayed kinetics, whereas BM CLPs were IL-7-responsive and rapidly generated B cells. ETPs sustained production of T lineage progeny for longer periods of time than BM CLPs. Analysis of Ikaros-deficient mice that exhibit ongoing thymopoiesis without B lymphopoeisis revealed near-normal frequencies of thymic ETPs, yet undetectable numbers of BM CLPs. We conclude that ETPs can develop via a CLP-independent pathway.
Comment in
- To T or not to T: reassessing the common lymphoid progenitor.
Montecino-Rodriguez E, Dorshkind K. Montecino-Rodriguez E, et al. Nat Immunol. 2003 Feb;4(2):100-1. doi: 10.1038/ni0203-100. Nat Immunol. 2003. PMID: 12555090 No abstract available.
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