Diminished pupillary light reflex at high irradiances in melanopsin-knockout mice - PubMed (original) (raw)
. 2003 Jan 10;299(5604):245-7.
doi: 10.1126/science.1077293.
Affiliations
- PMID: 12522249
- DOI: 10.1126/science.1077293
Diminished pupillary light reflex at high irradiances in melanopsin-knockout mice
R J Lucas et al. Science. 2003.
Abstract
In the mammalian retina, a small subset of retinal ganglion cells (RGCs) are intrinsically photosensitive, express the opsin-like protein melanopsin, and project to brain nuclei involved in non-image-forming visual functions such as pupillary light reflex and circadian photoentrainment. We report that in mice with the melanopsin gene ablated, RGCs retrograde-labeled from the suprachiasmatic nuclei were no longer intrinsically photosensitive, although their number, morphology, and projections were unchanged. These animals showed a pupillary light reflex indistinguishable from that of the wild type at low irradiances, but at high irradiances the reflex was incomplete, a pattern that suggests that the melanopsin-associated system and the classical rod/cone system are complementary in function.
Comment in
- Circadian rhythms. Circadian photoreception.
Menaker M. Menaker M. Science. 2003 Jan 10;299(5604):213-4. doi: 10.1126/science.1081112. Science. 2003. PMID: 12522238 No abstract available.
Similar articles
- Melanopsin is required for non-image-forming photic responses in blind mice.
Panda S, Provencio I, Tu DC, Pires SS, Rollag MD, Castrucci AM, Pletcher MT, Sato TK, Wiltshire T, Andahazy M, Kay SA, Van Gelder RN, Hogenesch JB. Panda S, et al. Science. 2003 Jul 25;301(5632):525-7. doi: 10.1126/science.1086179. Epub 2003 Jun 26. Science. 2003. PMID: 12829787 - Residual photosensitivity in mice lacking both rod opsin and cone photoreceptor cyclic nucleotide gated channel 3 alpha subunit.
Barnard AR, Appleford JM, Sekaran S, Chinthapalli K, Jenkins A, Seeliger M, Biel M, Humphries P, Douglas RH, Wenzel A, Foster RG, Hankins MW, Lucas RJ. Barnard AR, et al. Vis Neurosci. 2004 Sep-Oct;21(5):675-83. doi: 10.1017/S0952523804215024. Vis Neurosci. 2004. PMID: 15683556 - Intrinsically photosensitive melanopsin retinal ganglion cell contributions to the pupillary light reflex and circadian rhythm.
Markwell EL, Feigl B, Zele AJ. Markwell EL, et al. Clin Exp Optom. 2010 May;93(3):137-49. doi: 10.1111/j.1444-0938.2010.00479.x. Clin Exp Optom. 2010. PMID: 20557555 Review. - Two types of melanopsin retinal ganglion cell differentially innervate the hypothalamic suprachiasmatic nucleus and the olivary pretectal nucleus.
Baver SB, Pickard GE, Sollars PJ, Pickard GE. Baver SB, et al. Eur J Neurosci. 2008 Apr;27(7):1763-70. doi: 10.1111/j.1460-9568.2008.06149.x. Epub 2008 Mar 25. Eur J Neurosci. 2008. PMID: 18371076 - Multiple photoreceptors contribute to nonimage-forming visual functions predominantly through melanopsin-containing retinal ganglion cells.
Güler AD, Altimus CM, Ecker JL, Hattar S. Güler AD, et al. Cold Spring Harb Symp Quant Biol. 2007;72:509-15. doi: 10.1101/sqb.2007.72.074. Cold Spring Harb Symp Quant Biol. 2007. PMID: 18522518 Review.
Cited by
- Reversal of end-stage retinal degeneration and restoration of visual function by photoreceptor transplantation.
Singh MS, Charbel Issa P, Butler R, Martin C, Lipinski DM, Sekaran S, Barnard AR, MacLaren RE. Singh MS, et al. Proc Natl Acad Sci U S A. 2013 Jan 15;110(3):1101-6. doi: 10.1073/pnas.1119416110. Epub 2013 Jan 3. Proc Natl Acad Sci U S A. 2013. PMID: 23288902 Free PMC article. - Eye-specific visual processing in the mouse suprachiasmatic nuclei.
Walmsley L, Brown TM. Walmsley L, et al. J Physiol. 2015 Apr 1;593(7):1731-43. doi: 10.1113/jphysiol.2014.288225. Epub 2015 Feb 27. J Physiol. 2015. PMID: 25652666 Free PMC article. - A visual circuit uses complementary mechanisms to support transient and sustained pupil constriction.
Keenan WT, Rupp AC, Ross RA, Somasundaram P, Hiriyanna S, Wu Z, Badea TC, Robinson PR, Lowell BB, Hattar SS. Keenan WT, et al. Elife. 2016 Sep 26;5:e15392. doi: 10.7554/eLife.15392. Elife. 2016. PMID: 27669145 Free PMC article. - Using light to tell the time of day: sensory coding in the mammalian circadian visual network.
Brown TM. Brown TM. J Exp Biol. 2016 Jun 15;219(Pt 12):1779-92. doi: 10.1242/jeb.132167. J Exp Biol. 2016. PMID: 27307539 Free PMC article. Review. - Profound defects in pupillary responses to light in TRPM-channel null mice: a role for TRPM channels in non-image-forming photoreception.
Hughes S, Pothecary CA, Jagannath A, Foster RG, Hankins MW, Peirson SN. Hughes S, et al. Eur J Neurosci. 2012 Jan;35(1):34-43. doi: 10.1111/j.1460-9568.2011.07944.x. Eur J Neurosci. 2012. PMID: 22211741 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
- R01 EY006837/EY/NEI NIH HHS/United States
- R01 EY014596/EY/NEI NIH HHS/United States
- R37 EY006837-15S1/EY/NEI NIH HHS/United States
- R01 EY014596-01/EY/NEI NIH HHS/United States
- R37 EY006837/EY/NEI NIH HHS/United States
- R37 EY006837-13/EY/NEI NIH HHS/United States
- R37 EY006837-14/EY/NEI NIH HHS/United States
- R01 EY006837-16A1/EY/NEI NIH HHS/United States
- R37 EY006837-15/EY/NEI NIH HHS/United States
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases