A unique role for IL-23 in promoting cellular immunity - PubMed (original) (raw)
Review
A unique role for IL-23 in promoting cellular immunity
Carla S R Lankford et al. J Leukoc Biol. 2003 Jan.
Abstract
Recent discoveries of interleukin (IL)-23, its receptor, and its signal-transduction pathway add to our understanding of cellular immunity. IL-23 is a heterodimer, comprising IL-12 p40 and the recently cloned IL-23-specific p19 subunit. IL-23 uses many of the same signal-transduction components as IL-12, including IL-12Rbeta1, Janus kinase 2, Tyk2, signal transducer and activator of transcription (Stat)1, Stat3, Stat4, and Stat5. This may explain the similar actions of IL-12 and IL-23 in promoting cellular immunity by inducing interferon-gamma production and proliferative responses in target cells. Additionally, both cytokines promote the T helper cell type 1 costimulatory function of antigen-presenting cells. IL-23 does differ from IL-12 in the T cell subsets that it targets. Whereas IL-12 acts on naïve CD4+ T cells, IL-23 preferentially acts on memory CD4+ T cells. This review summarizes recent advances regarding IL-23, providing a functional and mechanistic basis for the unique niche that IL-23 occupies in cellular immunity.
Similar articles
- Signaling by IL-12 and IL-23 and the immunoregulatory roles of STAT4.
Watford WT, Hissong BD, Bream JH, Kanno Y, Muul L, O'Shea JJ. Watford WT, et al. Immunol Rev. 2004 Dec;202:139-56. doi: 10.1111/j.0105-2896.2004.00211.x. Immunol Rev. 2004. PMID: 15546391 Review. - Effects of IL-12 and IL-23 on antigen-presenting cells at the interface between innate and adaptive immunity.
Puccetti P, Belladonna ML, Grohmann U. Puccetti P, et al. Crit Rev Immunol. 2002;22(5-6):373-90. Crit Rev Immunol. 2002. PMID: 12803317 Review. - The power of combinatorial immunology: IL-12 and IL-12-related dimeric cytokines in infectious diseases.
Hölscher C. Hölscher C. Med Microbiol Immunol. 2004 Feb;193(1):1-17. doi: 10.1007/s00430-003-0186-x. Epub 2003 Jun 27. Med Microbiol Immunol. 2004. PMID: 12836019 Review. - Residual type 1 immunity in patients genetically deficient for interleukin 12 receptor beta1 (IL-12Rbeta1): evidence for an IL-12Rbeta1-independent pathway of IL-12 responsiveness in human T cells.
Verhagen CE, de Boer T, Smits HH, Verreck FA, Wierenga EA, Kurimoto M, Lammas DA, Kumararatne DS, Sanal O, Kroon FP, van Dissel JT, Sinigaglia F, Ottenhoff TH. Verhagen CE, et al. J Exp Med. 2000 Aug 21;192(4):517-28. doi: 10.1084/jem.192.4.517. J Exp Med. 2000. PMID: 10952721 Free PMC article. - Stepwise regulation of TH1 responses in autoimmunity: IL-12-related cytokines and their receptors.
Becker C, Wirtz S, Neurath MF. Becker C, et al. Inflamm Bowel Dis. 2005 Aug;11(8):755-64. doi: 10.1097/01.mib.0000172808.03877.4d. Inflamm Bowel Dis. 2005. PMID: 16043992 Review.
Cited by
- Induction of IL-2 by interleukin-12 p40 homodimer and IL-12, but not IL-23, in microglia and macrophages: Implications for multiple sclerosis.
Jana M, Mondal S, Jana A, Pahan K. Jana M, et al. Cytokine. 2024 Feb;174:156457. doi: 10.1016/j.cyto.2023.156457. Epub 2023 Dec 5. Cytokine. 2024. PMID: 38056248 - Roles of four targets in the pathogenesis of graves' orbitopathy.
Ren Z, Zhang H, Yu H, Zhu X, Lin J. Ren Z, et al. Heliyon. 2023 Aug 29;9(9):e19250. doi: 10.1016/j.heliyon.2023.e19250. eCollection 2023 Sep. Heliyon. 2023. PMID: 37810014 Free PMC article. Review. - Systemic Interleukins' Profile in Early and Advanced Colorectal Cancer.
Czajka-Francuz P, Cisoń-Jurek S, Czajka A, Kozaczka M, Wojnar J, Chudek J, Francuz T. Czajka-Francuz P, et al. Int J Mol Sci. 2021 Dec 23;23(1):124. doi: 10.3390/ijms23010124. Int J Mol Sci. 2021. PMID: 35008550 Free PMC article. Review. - STAT4: an immunoregulator contributing to diverse human diseases.
Yang C, Mai H, Peng J, Zhou B, Hou J, Jiang D. Yang C, et al. Int J Biol Sci. 2020 Mar 5;16(9):1575-1585. doi: 10.7150/ijbs.41852. eCollection 2020. Int J Biol Sci. 2020. PMID: 32226303 Free PMC article. Review. - Phenotypes of macrophages present in the intestine are impacted by stage of disease in cattle naturally infected with Mycobacterium avium subsp. paratuberculosis.
Jenvey CJ, Shircliff AL, Bannantine JP, Stabel JR. Jenvey CJ, et al. PLoS One. 2019 May 23;14(5):e0217649. doi: 10.1371/journal.pone.0217649. eCollection 2019. PLoS One. 2019. PMID: 31121006 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Research Materials
Miscellaneous