The chemical structure of prostaglandin X (prostacyclin) - PubMed (original) (raw)
The chemical structure of prostaglandin X (prostacyclin)
N Whittaker et al. Prostaglandins. 1976 Dec.
Abstract
The chemical structure of prostaglandin X, the anti-aggregatory substance derived from prostaglandin endoperoxides, is 9-deoxy-6, 6alpha-epoxy-delta5-PGF1alpha. The stable compound formed when prostaglandin X undergoes a chemical transformation in biological systems in 6-keto-PGF1alpha. Prostaglandin X is stabilized in aqueous preparations by raising the pH to 8.5 or higher. The trivial name prostacyclin is proposed for 9-deoxy-6, 9alpha-epoxy-delta5-PGF1alpha.
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