Eosinophilic gastroenteritis: a problem of the mucosal immune system? - PubMed (original) (raw)

Review

Eosinophilic gastroenteritis: a problem of the mucosal immune system?

Mi-Na Kweon et al. Curr Allergy Asthma Rep. 2003 Jan.

Abstract

The gastrointestinal immune system is a major component of the mucosal barrier, which provides an appropriate immunologic homeostasis between host and numerous foreign antigens, including microbial and dietary antigens. However, under certain pathological circumstances created by disturbance of the immunologic balance, allergic responses associated with the gastrointestinal tract can be triggered by abnormal immune responses against selected food protein antigens. Among the several types of immune competent cells, eosinophils are generally considered to play a central role for the development of allergic diseases in gastrointestinal tissue. Although most research has been focused on the molecular and cellular understanding of eosinophils in the peripheral tissues and lung, recent studies elucidate the unique trafficking and regulation mechanisms of eosinophils in the gastrointestinal tissues. In this review, we summarize current findings in the regulatory mechanism of gastrointestinal eosinophils. Furthermore, several unique murine models for eosinophilic gastroenteritis, which can be applied for the elucidation of underlying mechanisms of eosinophil-mediated gastrointestinal allergy, and the development of new mucosal immune therapy for the control of food allergy are reviewed.

PubMed Disclaimer

Similar articles

• The pathobiology of eosinophilic gastroenteritis of childhood: is it really the eosinophil, allergic mediated, or something else?
  Ngo P, Furuta G, Burks W. Ngo P, et al. Curr Gastroenterol Rep. 2004 Dec;6(6):436-40. doi: 10.1007/s11894-004-0064-8. Curr Gastroenterol Rep. 2004. PMID: 15527672 Review.
• A pathological function for eotaxin and eosinophils in eosinophilic gastrointestinal inflammation.
  Hogan SP, Mishra A, Brandt EB, Royalty MP, Pope SM, Zimmermann N, Foster PS, Rothenberg ME. Hogan SP, et al. Nat Immunol. 2001 Apr;2(4):353-60. doi: 10.1038/86365. Nat Immunol. 2001. PMID: 11276207
• Eosinophilic gastrointestinal disorders (EGID).
  Rothenberg ME. Rothenberg ME. J Allergy Clin Immunol. 2004 Jan;113(1):11-28; quiz 29. doi: 10.1016/j.jaci.2003.10.047. J Allergy Clin Immunol. 2004. PMID: 14713902 Review.
• The mucosal barrier, IgE-mediated gastrointestinal events, and eosinophilic gastroenteritis.
  Wershil BK, Walker WA. Wershil BK, et al. Gastroenterol Clin North Am. 1992 Jun;21(2):387-404. Gastroenterol Clin North Am. 1992. PMID: 1512048 Review.
• Eosinophil Function in Eosinophil-associated Gastrointestinal Disorders.
  Hogan SP, Rothenberg ME. Hogan SP, et al. Curr Allergy Asthma Rep. 2006 Feb;6(1):65-71. doi: 10.1007/s11882-006-0013-8. Curr Allergy Asthma Rep. 2006. PMID: 16476198 Review.

Cited by

• Aberrant interaction of the gut immune system with environmental factors in the development of food allergies.
  Kunisawa J, Kiyono H. Kunisawa J, et al. Curr Allergy Asthma Rep. 2010 May;10(3):215-21. doi: 10.1007/s11882-010-0097-z. Curr Allergy Asthma Rep. 2010. PMID: 20424996 Review.
• Eosinophilic gastroenteritis with eosinophilic dermatitis.
  Cha JM, Lee JI, Joo KR, Shin HP. Cha JM, et al. Yonsei Med J. 2010 Jan;51(1):145-7. doi: 10.3349/ymj.2010.51.1.145. Epub 2009 Dec 29. Yonsei Med J. 2010. PMID: 20046530 Free PMC article.
• Eosinophilic gastroenteritis with ascites and hepatic dysfunction.
  Zhou HB, Chen JM, Du Q. Zhou HB, et al. World J Gastroenterol. 2007 Feb 28;13(8):1303-5. doi: 10.3748/wjg.v13.i8.1303. World J Gastroenterol. 2007. PMID: 17451222 Free PMC article.
• Mast cells are required for experimental oral allergen-induced diarrhea.
  Brandt EB, Strait RT, Hershko D, Wang Q, Muntel EE, Scribner TA, Zimmermann N, Finkelman FD, Rothenberg ME. Brandt EB, et al. J Clin Invest. 2003 Dec;112(11):1666-77. doi: 10.1172/JCI19785. J Clin Invest. 2003. PMID: 14660743 Free PMC article.

References

1. 1. J Clin Invest. 1999 Jun;103(12):1719-27 - PubMed
2. 1. J Allergy Clin Immunol. 1996 Apr;97(4):889-92 - PubMed
3. 1. J Clin Invest. 2001 Jan;107(1):83-90 - PubMed
4. 1. J Clin Invest. 1996 Nov 15;98(10):2332-45 - PubMed
5. 1. Immunol Rev. 2001 Feb;179:139-55 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources

• Medical

  • MedlinePlus Health Information