Calorie restriction in rhesus monkeys - PubMed (original) (raw)
Calorie restriction in rhesus monkeys
Julie A Mattison et al. Exp Gerontol. 2003 Jan-Feb.
Abstract
Calorie restriction (CR) extends lifespan and reduces the incidence and age of onset of age-related disease in several animal models. To determine if this nutritional intervention has similar actions in a long-lived primate species, the National Institute on Aging (NIA) initiated a study in 1987 to investigate the effects of a 30% CR in male and female rhesus macaques (Macaca mulatta) of a broad age range. We have observed physiological effects of CR that parallel rodent studies and may be predictive of an increased lifespan. Specifically, results from the NIA study have demonstrated that CR decreases body weight and fat mass, improves glucoregulatory function, decreases blood pressure and blood lipids, and decreases body temperature. Juvenile males exhibited delayed skeletal and sexual maturation. Adult bone mass was not affected by CR in females nor were several reproductive hormones or menstrual cycling. CR attenuated the age-associated decline in both dehydroepiandrosterone (DHEA) and melatonin in males. Although 81% of the monkeys in the study are still alive, preliminary evidence suggests that CR will have beneficial effects on morbidity and mortality. We are now preparing a battery of measures to provide a thorough and relevant analysis of the effectiveness of CR at delaying the onset of age-related disease and maintaining function later into life.
Similar articles
- Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study.
Mattison JA, Roth GS, Beasley TM, Tilmont EM, Handy AM, Herbert RL, Longo DL, Allison DB, Young JE, Bryant M, Barnard D, Ward WF, Qi W, Ingram DK, de Cabo R. Mattison JA, et al. Nature. 2012 Sep 13;489(7415):318-21. doi: 10.1038/nature11432. Nature. 2012. PMID: 22932268 Free PMC article. - Short-term calorie restriction improves disease-related markers in older male rhesus monkeys (Macaca mulatta).
Lane MA, Tilmont EM, De Angelis H, Handy A, Ingram DK, Kemnitz JW, Roth GS. Lane MA, et al. Mech Ageing Dev. 2000 Jan 10;112(3):185-96. doi: 10.1016/s0047-6374(99)00087-1. Mech Ageing Dev. 2000. PMID: 10687924 - Caloric restriction in primates.
Lane MA, Black A, Handy A, Tilmont EM, Ingram DK, Roth GS. Lane MA, et al. Ann N Y Acad Sci. 2001 Apr;928:287-95. doi: 10.1111/j.1749-6632.2001.tb05658.x. Ann N Y Acad Sci. 2001. PMID: 11795520 Review. - Energy restriction does not alter bone mineral metabolism or reproductive cycling and hormones in female rhesus monkeys.
Lane MA, Black A, Handy AM, Shapses SA, Tilmont EM, Kiefer TL, Ingram DK, Roth GS. Lane MA, et al. J Nutr. 2001 Mar;131(3):820-7. doi: 10.1093/jn/131.3.820. J Nutr. 2001. PMID: 11238765 - Effects of reduced energy intake on the biology of aging: the primate model.
Roth GS, Ingram DK, Black A, Lane MA. Roth GS, et al. Eur J Clin Nutr. 2000 Jun;54 Suppl 3:S15-20. doi: 10.1038/sj.ejcn.1601020. Eur J Clin Nutr. 2000. PMID: 11041070 Review.
Cited by
- Cardiac aging: from molecular mechanisms to significance in human health and disease.
Dai DF, Chen T, Johnson SC, Szeto H, Rabinovitch PS. Dai DF, et al. Antioxid Redox Signal. 2012 Jun 15;16(12):1492-526. doi: 10.1089/ars.2011.4179. Epub 2012 Apr 3. Antioxid Redox Signal. 2012. PMID: 22229339 Free PMC article. Review. - Quality control systems in cardiac aging.
Quarles EK, Dai DF, Tocchi A, Basisty N, Gitari L, Rabinovitch PS. Quarles EK, et al. Ageing Res Rev. 2015 Sep;23(Pt A):101-15. doi: 10.1016/j.arr.2015.02.003. Epub 2015 Feb 19. Ageing Res Rev. 2015. PMID: 25702865 Free PMC article. Review. - Convergence in reduced body size, head size, and blood glucose in three island reptiles.
Sparkman AM, Clark AD, Brummett LJ, Chism KR, Combrink LL, Kabey NM, Schwartz TS. Sparkman AM, et al. Ecol Evol. 2018 May 20;8(12):6169-6182. doi: 10.1002/ece3.4171. eCollection 2018 Jun. Ecol Evol. 2018. PMID: 29988440 Free PMC article. - Mitochondrial neuronal uncoupling proteins: a target for potential disease-modification in Parkinson's disease.
Ho PW, Ho JW, Liu HF, So DH, Tse ZH, Chan KH, Ramsden DB, Ho SL. Ho PW, et al. Transl Neurodegener. 2012 Jan 13;1(1):3. doi: 10.1186/2047-9158-1-3. Transl Neurodegener. 2012. PMID: 23210978 Free PMC article. - Caloric restriction increases neurotrophic factor levels and attenuates neurochemical and behavioral deficits in a primate model of Parkinson's disease.
Maswood N, Young J, Tilmont E, Zhang Z, Gash DM, Gerhardt GA, Grondin R, Roth GS, Mattison J, Lane MA, Carson RE, Cohen RM, Mouton PR, Quigley C, Mattson MP, Ingram DK. Maswood N, et al. Proc Natl Acad Sci U S A. 2004 Dec 28;101(52):18171-6. doi: 10.1073/pnas.0405831102. Epub 2004 Dec 16. Proc Natl Acad Sci U S A. 2004. PMID: 15604149 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical