Early intraneuronal Abeta deposition in the hippocampus of APP transgenic mice - PubMed (original) (raw)
Early intraneuronal Abeta deposition in the hippocampus of APP transgenic mice
Feng-Shiun Shie et al. Neuroreport. 2003.
Erratum in
- Neuroreport. 2004 Aug 26;15(12):1993. LeBoeur, Renée C [corrected to LeBoeuf, Renée C]
Abstract
Increasing evidence suggests that intraneuronal amyloid-beta (Abeta) accumulation may be an early event in Alzheimer's disease (AD) pathogenesis. However direct in vivo evidence regarding initial Abeta seeding is missing. Using an APP transgenic mouse model, our sensitive immunocytochemical procedures revealed a novel intraneuronal Abeta deposition in the somas of hippocampal CA1/subiculum neurons far in advance of the occurrence of extracellular Abetaplaques. These deposits increased exponentially with age and were elevated approximately 4-fold (p < 0.001) by high fat/high cholesterol diet. Abeta40 and Abeta42 were the major constituents of these deposits and were co-localized with lysosomal markers. Our results are consistent with the notion that the earliest Abeta deposition occurs intraneuronally, prior to extracellular amyloid plaque formation.
Copyright 2003 Lippincott Williams & Wilkins
Similar articles
- Deposition of mouse amyloid beta in human APP/PS1 double and single AD model transgenic mice.
van Groen T, Kiliaan AJ, Kadish I. van Groen T, et al. Neurobiol Dis. 2006 Sep;23(3):653-62. doi: 10.1016/j.nbd.2006.05.010. Epub 2006 Jul 10. Neurobiol Dis. 2006. PMID: 16829076 - The Arctic Alzheimer mutation facilitates early intraneuronal Abeta aggregation and senile plaque formation in transgenic mice.
Lord A, Kalimo H, Eckman C, Zhang XQ, Lannfelt L, Nilsson LN. Lord A, et al. Neurobiol Aging. 2006 Jan;27(1):67-77. doi: 10.1016/j.neurobiolaging.2004.12.007. Epub 2005 Feb 17. Neurobiol Aging. 2006. PMID: 16298242 - Age-related accumulation of Reelin in amyloid-like deposits.
Knuesel I, Nyffeler M, Mormède C, Muhia M, Meyer U, Pietropaolo S, Yee BK, Pryce CR, LaFerla FM, Marighetto A, Feldon J. Knuesel I, et al. Neurobiol Aging. 2009 May;30(5):697-716. doi: 10.1016/j.neurobiolaging.2007.08.011. Epub 2007 Sep 27. Neurobiol Aging. 2009. PMID: 17904250 - [The lesions of Alzheimer's disease: which therapeutic perspectives?].
Duyckaerts C, Perruchini C, Lebouvier T, Potier MC. Duyckaerts C, et al. Bull Acad Natl Med. 2008 Feb;192(2):303-18; discussion 318-21. Bull Acad Natl Med. 2008. PMID: 18819685 Review. French. - Review on the APP/PS1KI mouse model: intraneuronal Abeta accumulation triggers axonopathy, neuron loss and working memory impairment.
Bayer TA, Wirths O. Bayer TA, et al. Genes Brain Behav. 2008 Feb;7 Suppl 1:6-11. doi: 10.1111/j.1601-183X.2007.00372.x. Genes Brain Behav. 2008. PMID: 18184366 Review.
Cited by
- Co-occurrence of Alzheimer's disease ß-amyloid and τ pathologies at synapses.
Takahashi RH, Capetillo-Zarate E, Lin MT, Milner TA, Gouras GK. Takahashi RH, et al. Neurobiol Aging. 2010 Jul;31(7):1145-52. doi: 10.1016/j.neurobiolaging.2008.07.021. Epub 2008 Sep 3. Neurobiol Aging. 2010. PMID: 18771816 Free PMC article. - Abnormal tau, mitochondrial dysfunction, impaired axonal transport of mitochondria, and synaptic deprivation in Alzheimer's disease.
Reddy PH. Reddy PH. Brain Res. 2011 Sep 30;1415:136-48. doi: 10.1016/j.brainres.2011.07.052. Epub 2011 Jul 31. Brain Res. 2011. PMID: 21872849 Free PMC article. Review. - Microglia receptors and their implications in the response to amyloid β for Alzheimer's disease pathogenesis.
Doens D, Fernández PL. Doens D, et al. J Neuroinflammation. 2014 Mar 13;11:48. doi: 10.1186/1742-2094-11-48. J Neuroinflammation. 2014. PMID: 24625061 Free PMC article. Review. - Icariside II, a Broad-Spectrum Anti-cancer Agent, Reverses Beta-Amyloid-Induced Cognitive Impairment through Reducing Inflammation and Apoptosis in Rats.
Deng Y, Long L, Wang K, Zhou J, Zeng L, He L, Gong Q. Deng Y, et al. Front Pharmacol. 2017 Feb 2;8:39. doi: 10.3389/fphar.2017.00039. eCollection 2017. Front Pharmacol. 2017. PMID: 28210222 Free PMC article. - Modulation of LPS-Induced Neurodegeneration by Intestinal Helminth Infection in Ageing Mice.
Jermakow N, Skarżyńska W, Lewandowska K, Kiernozek E, Goździk K, Mietelska-Porowska A, Drela N, Wojda U, Doligalska M. Jermakow N, et al. Int J Mol Sci. 2023 Sep 12;24(18):13994. doi: 10.3390/ijms241813994. Int J Mol Sci. 2023. PMID: 37762297 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
Miscellaneous