Random mutagenesis in the mouse as a tool in drug discovery - PubMed (original) (raw)
Review
Random mutagenesis in the mouse as a tool in drug discovery
Andreas Russ et al. Drug Discov Today. 2002.
Abstract
The flood of raw information generated by large-scale data acquisition technologies in genomics, microarrays and proteomics is changing the early stages of the drug discovery process. Although many more potential drug targets are now available compared with the pre-genomics era, knowledge about the physiological context in which these targets act--information crucial to both discovery and development--is scarce. Random mutagenesis strategies in the mouse provide scalable approaches for both the gene-driven validation of candidate targets in vivo and the discovery of new physiological pathways by phenotype-driven screens.
Comment in
- Drug discovery perspective of chemical-driven mouse mutagenesis.
Xie W, Uppal H. Xie W, et al. Drug Discov Today. 2003 Mar 1;8(5):199. doi: 10.1016/s1359-6446(03)02619-9. Drug Discov Today. 2003. PMID: 12634009 No abstract available. - ENU mutagenesis for pharma.
Adams MD. Adams MD. Drug Discov Today. 2003 Mar 1;8(5):199-200. doi: 10.1016/s1359-6446(03)02621-7. Drug Discov Today. 2003. PMID: 12634010 No abstract available.
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