Autonomic dysfunction associates with prolongation of QT intervals and blunted night BP in obese women with visceral obesity - PubMed (original) (raw)
. 2002 Dec;25(11):RC32-5.
doi: 10.1007/BF03344061.
Affiliations
- PMID: 12553548
- DOI: 10.1007/BF03344061
Autonomic dysfunction associates with prolongation of QT intervals and blunted night BP in obese women with visceral obesity
K Esposito et al. J Endocrinol Invest. 2002 Dec.
Abstract
Prolonged QT intervals and a reduced fall of nocturnal blood pressure (BP) both predict an increased risk of cardiovascular events in obese subjects. We evaluated circadian BP variations (24-h ambulatory BP monitoring), autonomic function (power spectral analysis of RR interval oscillations) and cardiac repolarization times (QTc-dispersion and QTc interval) in 70 obese women, aged 25-44 yr, grouped by WHR into group A (WHR > 0.85, no.=38) and group B (WHR < or = 0.85, no.=32). Compared with non-obese age-matched women (no.=25, BMI=23+/-1.8) and obese women of group B, obese women of group A had higher values of QTc-d (p<0.05) and QTc (p<0.05), an altered sympathovagal balance (ratio of low-frequency/high-frequency power, p<0.01), and a blunted nocturnal drop in BP (p<0.01). In group A, QTc-d and the QTc interval correlated with diastolic night BP (p<0.01) and sympathovagal balance (p<0.01). WHR and plasma insulin levels correlated with QT intervals, reduced nocturnal fall in diastolic BP and sympathovagal balance (p<0.01). Prolongation of cardiac repolarization times and the reduction of nocturnal fall in BP coexist in obese women with visceral obesity, and might contribute to their raised cardiovascular risk. Autonomic dysfunction may be the common mechanism for this association.
Similar articles
- Sympathovagal balance, nighttime blood pressure, and QT intervals in normotensive obese women.
Esposito K, Marfella R, Gualdiero P, Carusone C, Pontillo A, Giugliano G, Nicoletti G, Giugliano D. Esposito K, et al. Obes Res. 2003 May;11(5):653-9. doi: 10.1038/oby.2003.93. Obes Res. 2003. PMID: 12740455 - Increased QTc dispersion is related to blunted circadian blood pressure variation in normoalbuminuric type 1 diabetic patients.
Poulsen PL, Ebbehøj E, Arildsen H, Knudsen ST, Hansen KW, Mølgaard H, Mogensen CE. Poulsen PL, et al. Diabetes. 2001 Apr;50(4):837-42. doi: 10.2337/diabetes.50.4.837. Diabetes. 2001. PMID: 11289050 - Influence of cardiac autonomic neuropathy on heart rate dependence of ventricular repolarization in diabetic patients.
Valensi PE, Johnson NB, Maison-Blanche P, Extramania F, Motte G, Coumel P. Valensi PE, et al. Diabetes Care. 2002 May;25(5):918-23. doi: 10.2337/diacare.25.5.918. Diabetes Care. 2002. PMID: 11978691 - Assessment of cardiac autonomic modulation during adolescent obesity.
Rabbia F, Silke B, Conterno A, Grosso T, De Vito B, Rabbone I, Chiandussi L, Veglio F. Rabbia F, et al. Obes Res. 2003 Apr;11(4):541-8. doi: 10.1038/oby.2003.76. Obes Res. 2003. PMID: 12690083 - FFAs and QT intervals in obese women with visceral adiposity: effects of sustained weight loss over 1 year.
Corbi GM, Carbone S, Ziccardi P, Giugliano G, Marfella R, Nappo F, Paolisso G, Esposito K, Giugliano D. Corbi GM, et al. J Clin Endocrinol Metab. 2002 May;87(5):2080-3. doi: 10.1210/jcem.87.5.8516. J Clin Endocrinol Metab. 2002. PMID: 11994344
Cited by
- Adiposity and Cardiac Defects: Pathophysiology and Etiology.
Koparkar G, Biswas DA. Koparkar G, et al. Cureus. 2023 Jan 21;15(1):e34026. doi: 10.7759/cureus.34026. eCollection 2023 Jan. Cureus. 2023. PMID: 36824557 Free PMC article. Review. - Eosinophilic Infiltration of the Sino-Atrial Node in Sudden Cardiac Death Caused by Long QT Syndrome.
Grassi S, Campuzano O, Coll M, Cazzato F, Iglesias A, Ausania F, Scarnicci F, Sarquella-Brugada G, Brugada J, Arena V, Oliva A, Brugada R. Grassi S, et al. Int J Mol Sci. 2022 Oct 1;23(19):11666. doi: 10.3390/ijms231911666. Int J Mol Sci. 2022. PMID: 36232963 Free PMC article. - Is there a relationship between epicardial fat tissue thickness and Tp-Te/QT ratio in healthy individuals?
Yılmaz M, Kayançiçek H, Gözel N, Kurtoğlu E, Seçen Ö, Öner P, Çekici Y, Bilen MN, Demirkıran S, Uku Ö. Yılmaz M, et al. Arch Med Sci Atheroscler Dis. 2020 Jun 5;5:e127-e139. doi: 10.5114/aoms.2020.96147. eCollection 2020. Arch Med Sci Atheroscler Dis. 2020. PMID: 32665987 Free PMC article. - QT interval Independently Predicts Mortality and Heart Failure in Patients with ST-Elevation Myocardial Infarction.
Lin JF, Hsu SY, Wu S, Teng MS, Chou HH, Cheng ST, Wu TY, Ko YL. Lin JF, et al. Int J Med Sci. 2015 Nov 17;12(12):968-73. doi: 10.7150/ijms.13121. eCollection 2015. Int J Med Sci. 2015. PMID: 26664258 Free PMC article. - Dispersion of ventricular repolarization in relation to cardiovascular risk factors in hypertension.
Ciobanu A, Gheorghe GS, Ababei M, Deaconu M, Ilieşiu AM, Bolohan M, Păun N, Nicolae C, Nanea IT. Ciobanu A, et al. J Med Life. 2014 Oct-Dec;7(4):545-50. J Med Life. 2014. PMID: 25713619 Free PMC article.
References
- Lancet. 1997 Dec 20-27;350(9094):1821-2 - PubMed
- Int J Obes. 1983;7(3):253-61 - PubMed
- Arch Intern Med. 1997 Nov 24;157(21):2413-46 - PubMed
- Cardiol Rev. 2001 Jul-Aug;9(4):202-7 - PubMed
- Circulation. 1994 Aug;90(2):779-85 - PubMed
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical