Cutting edge: carbohydrate profiling identifies new pathogens that interact with dendritic cell-specific ICAM-3-grabbing nonintegrin on dendritic cells - PubMed (original) (raw)
Cutting edge: carbohydrate profiling identifies new pathogens that interact with dendritic cell-specific ICAM-3-grabbing nonintegrin on dendritic cells
Ben J Appelmelk et al. J Immunol. 2003.
Abstract
Dendritic cells (DC) are instrumental in handling pathogens for processing and presentation to T cells, thus eliciting an appropriate immune response. C-type lectins expressed by DC function as pathogen-recognition receptors; yet their specificity for carbohydrate structures on pathogens is not fully understood. In this study, we analyzed the carbohydrate specificity of DC-specific ICAM-3-grabbing nonintegrin (SIGN)/CD209, the recently documented HIV-1 receptor on DC. Our studies show that DC-SIGN binds with high affinity to both synthetic mannose- and fucose-containing glycoconjugates. These carbohydrate structures are abundantly expressed by pathogens as demonstrated by the affinity of DC-SIGN for natural surface glycans of the human pathogens Mycobacterium tuberculosis, Helicobacter pylori, Leishmania mexicana, and Schistosoma mansoni. This analysis expands our knowledge on the carbohydrate and pathogen-specificity of DC-SIGN and identifies this lectin to be central in pathogen-DC interactions.
Similar articles
- The dendritic cell-specific C-type lectin DC-SIGN is a receptor for Schistosoma mansoni egg antigens and recognizes the glycan antigen Lewis x.
van Die I, van Vliet SJ, Nyame AK, Cummings RD, Bank CM, Appelmelk B, Geijtenbeek TB, van Kooyk Y. van Die I, et al. Glycobiology. 2003 Jun;13(6):471-8. doi: 10.1093/glycob/cwg052. Epub 2003 Feb 20. Glycobiology. 2003. PMID: 12626400 - Carbohydrate-specific signaling through the DC-SIGN signalosome tailors immunity to Mycobacterium tuberculosis, HIV-1 and Helicobacter pylori.
Gringhuis SI, den Dunnen J, Litjens M, van der Vlist M, Geijtenbeek TB. Gringhuis SI, et al. Nat Immunol. 2009 Oct;10(10):1081-8. doi: 10.1038/ni.1778. Epub 2009 Aug 30. Nat Immunol. 2009. PMID: 19718030 - Dendritic cell (DC)-specific intercellular adhesion molecule 3 (ICAM-3)-grabbing nonintegrin (DC-SIGN, CD209), a C-type surface lectin in human DCs, is a receptor for Leishmania amastigotes.
Colmenares M, Puig-Kröger A, Pello OM, Corbí AL, Rivas L. Colmenares M, et al. J Biol Chem. 2002 Sep 27;277(39):36766-9. doi: 10.1074/jbc.M205270200. Epub 2002 Jul 16. J Biol Chem. 2002. PMID: 12122001 - A fatal attraction: Mycobacterium tuberculosis and HIV-1 target DC-SIGN to escape immune surveillance.
van Kooyk Y, Appelmelk B, Geijtenbeek TB. van Kooyk Y, et al. Trends Mol Med. 2003 Apr;9(4):153-9. doi: 10.1016/s1471-4914(03)00027-3. Trends Mol Med. 2003. PMID: 12727141 Review. - DC-SIGN: escape mechanism for pathogens.
van Kooyk Y, Geijtenbeek TB. van Kooyk Y, et al. Nat Rev Immunol. 2003 Sep;3(9):697-709. doi: 10.1038/nri1182. Nat Rev Immunol. 2003. PMID: 12949494 Review.
Cited by
- Synthesis and screening of a library of Lewisx deoxyfluoro-analogues reveals differential recognition by glycan-binding partners.
Hollingsworth K, Di Maio A, Richards SJ, Vendeville JB, Wheatley DE, Council CE, Keenan T, Ledru H, Chidwick H, Huang K, Parmeggiani F, Marchesi A, Chai W, McBerney R, Kamiński TP, Balmforth MR, Tamasanu A, Finnigan JD, Young C, Warriner SL, Webb ME, Fascione MA, Flitsch S, Galan MC, Feizi T, Gibson MI, Liu Y, Turnbull WB, Linclau B. Hollingsworth K, et al. Nat Commun. 2024 Sep 13;15(1):7925. doi: 10.1038/s41467-024-51081-7. Nat Commun. 2024. PMID: 39271664 Free PMC article. - DC-SIGN of Largemouth Bass (Micropterus salmoides) Mediates Immune Functions against Aeromonas hydrophila through Collaboration with the TLR Signaling Pathway.
Huang M, Liu J, Yuan Z, Xu Y, Guo Y, Yang S, Fei H. Huang M, et al. Int J Mol Sci. 2024 May 3;25(9):5013. doi: 10.3390/ijms25095013. Int J Mol Sci. 2024. PMID: 38732232 Free PMC article. - Non-targeted isomer-sensitive N-glycome analysis reveals new layers of organ-specific diversity in mice.
Stadlmann J, Helm J, Mereiter S, Oliveira T, Gattinger A, Markovitz D, Penninger J, Altmann F. Stadlmann J, et al. Res Sq [Preprint]. 2024 Apr 9:rs.3.rs-4130712. doi: 10.21203/rs.3.rs-4130712/v1. Res Sq. 2024. PMID: 38659835 Free PMC article. Preprint. - Strategies of Helicobacter pylori in evading host innate and adaptive immunity: insights and prospects for therapeutic targeting.
Fan J, Zhu J, Xu H. Fan J, et al. Front Cell Infect Microbiol. 2024 Feb 26;14:1342913. doi: 10.3389/fcimb.2024.1342913. eCollection 2024. Front Cell Infect Microbiol. 2024. PMID: 38469348 Free PMC article. Review. - Helicobacter pylori Infection and Chronic Immune Thrombocytopenia.
Takeuchi H, Okamoto A. Takeuchi H, et al. J Clin Med. 2022 Aug 17;11(16):4822. doi: 10.3390/jcm11164822. J Clin Med. 2022. PMID: 36013059 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases