Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide - PubMed (original) (raw)

. 2003 Feb 7;299(5608):896-9.

doi: 10.1126/science.1079368.

Affiliations

• PMID: 12574632
• DOI: 10.1126/science.1079368

Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide

Enzo Nisoli et al. Science. 2003.

Abstract

Nitric oxide was found to trigger mitochondrial biogenesis in cells as diverse as brown adipocytes and 3T3-L1, U937, and HeLa cells. This effect of nitric oxide was dependent on guanosine 3',5'-monophosphate (cGMP) and was mediated by the induction of peroxisome proliferator-activated receptor gamma coactivator 1alpha, a master regulator of mitochondrial biogenesis. Moreover, the mitochondrial biogenesis induced by exposure to cold was markedly reduced in brown adipose tissue of endothelial nitric oxide synthase null-mutant (eNOS-/-) mice, which had a reduced metabolic rate and accelerated weight gain as compared to wild-type mice. Thus, a nitric oxide-cGMP-dependent pathway controls mitochondrial biogenesis and body energy balance.

PubMed Disclaimer

Comment in

• Cell biology. NO says yes to mitochondria.
  Brown GC. Brown GC. Science. 2003 Feb 7;299(5608):838-9. doi: 10.1126/science.1082028. Science. 2003. PMID: 12574611 No abstract available.
• Mitochondrial biogenesis: which part of "NO" do we understand?
  Leary SC, Shoubridge EA. Leary SC, et al. Bioessays. 2003 Jun;25(6):538-41. doi: 10.1002/bies.10298. Bioessays. 2003. PMID: 12766943 Review.

Similar articles

• Cell biology. NO says yes to mitochondria.
  Brown GC. Brown GC. Science. 2003 Feb 7;299(5608):838-9. doi: 10.1126/science.1082028. Science. 2003. PMID: 12574611 No abstract available.
• Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS.
  Nisoli E, Tonello C, Cardile A, Cozzi V, Bracale R, Tedesco L, Falcone S, Valerio A, Cantoni O, Clementi E, Moncada S, Carruba MO. Nisoli E, et al. Science. 2005 Oct 14;310(5746):314-7. doi: 10.1126/science.1117728. Science. 2005. PMID: 16224023
• TNF-alpha downregulates eNOS expression and mitochondrial biogenesis in fat and muscle of obese rodents.
  Valerio A, Cardile A, Cozzi V, Bracale R, Tedesco L, Pisconti A, Palomba L, Cantoni O, Clementi E, Moncada S, Carruba MO, Nisoli E. Valerio A, et al. J Clin Invest. 2006 Oct;116(10):2791-8. doi: 10.1172/JCI28570. Epub 2006 Sep 14. J Clin Invest. 2006. PMID: 16981010 Free PMC article.
• Regulatory role for the arginine-nitric oxide pathway in metabolism of energy substrates.
  Jobgen WS, Fried SK, Fu WJ, Meininger CJ, Wu G. Jobgen WS, et al. J Nutr Biochem. 2006 Sep;17(9):571-88. doi: 10.1016/j.jnutbio.2005.12.001. Epub 2006 Jan 9. J Nutr Biochem. 2006. PMID: 16524713 Review.
• Mitochondrial biogenesis: which part of "NO" do we understand?
  Leary SC, Shoubridge EA. Leary SC, et al. Bioessays. 2003 Jun;25(6):538-41. doi: 10.1002/bies.10298. Bioessays. 2003. PMID: 12766943 Review.

Cited by

• Biology of mitochondria in neurodegenerative diseases.
  Martin LJ. Martin LJ. Prog Mol Biol Transl Sci. 2012;107:355-415. doi: 10.1016/B978-0-12-385883-2.00005-9. Prog Mol Biol Transl Sci. 2012. PMID: 22482456 Free PMC article. Review.
• Role of mitochondrial dysfunction and altered autophagy in cardiovascular aging and disease: from mechanisms to therapeutics.
  Marzetti E, Csiszar A, Dutta D, Balagopal G, Calvani R, Leeuwenburgh C. Marzetti E, et al. Am J Physiol Heart Circ Physiol. 2013 Aug 15;305(4):H459-76. doi: 10.1152/ajpheart.00936.2012. Epub 2013 Jun 7. Am J Physiol Heart Circ Physiol. 2013. PMID: 23748424 Free PMC article. Review.
• Endogenous asymmetric dimethylarginine accumulation contributes to the suppression of myocardial mitochondrial biogenesis in type 2 diabetic rats.
  Xiong Y, Hai CX, Fang WJ, Lei YP, Li XM, Zhou XK. Xiong Y, et al. Nutr Metab (Lond). 2020 Aug 24;17:72. doi: 10.1186/s12986-020-00486-4. eCollection 2020. Nutr Metab (Lond). 2020. PMID: 32855652 Free PMC article.
• Late-life enalapril administration induces nitric oxide-dependent and independent metabolic adaptations in the rat skeletal muscle.
  Marzetti E, Calvani R, DuPree J, Lees HA, Giovannini S, Seo DO, Buford TW, Sweet K, Morgan D, Strehler KY, Diz D, Borst SE, Moningka N, Krotova K, Carter CS. Marzetti E, et al. Age (Dordr). 2013 Aug;35(4):1061-75. doi: 10.1007/s11357-012-9428-4. Epub 2012 May 26. Age (Dordr). 2013. PMID: 22639176 Free PMC article.
• Plant molecules reinforce bone repair: Novel insights into phenol-modified bone tissue engineering scaffolds for the treatment of bone defects.
  Chen Y, Gan W, Cheng Z, Zhang A, Shi P, Zhang Y. Chen Y, et al. Mater Today Bio. 2023 Dec 21;24:100920. doi: 10.1016/j.mtbio.2023.100920. eCollection 2024 Feb. Mater Today Bio. 2023. PMID: 38226013 Free PMC article. Review.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Atypon
  • Ovid Technologies, Inc.

• Other Literature Sources

  • H1 Connect
  • The Lens - Patent Citations Database

• Molecular Biology Databases

  • Gene Ontology
  • Mouse Genome Informatics (MGI)