GUN4, a regulator of chlorophyll synthesis and intracellular signaling - PubMed (original) (raw)
. 2003 Feb 7;299(5608):902-6.
doi: 10.1126/science.1079978.
Affiliations
- PMID: 12574634
- DOI: 10.1126/science.1079978
GUN4, a regulator of chlorophyll synthesis and intracellular signaling
Robert M Larkin et al. Science. 2003.
Abstract
Nuclear genes control plastid differentiation in response to developmental signals, environmental signals, and retrograde signals from plastids themselves. In return, plastids emit signals that are essential for proper expression of many nuclear photosynthetic genes. Accumulation of magnesium-protoporphyrin IX (Mg-Proto), an intermediate in chlorophyll biosynthesis, is a plastid signal that represses nuclear transcription through a signaling pathway that, in Arabidopsis, requires the GUN4 gene. GUN4 binds the product and substrate of Mg- chelatase, an enzyme that produces Mg-Proto, and activates Mg-chelatase. Thus, GUN4 participates in plastid-to-nucleus signaling by regulating Mg-Proto synthesis or trafficking.
Similar articles
- Structural and biochemical characterization of Gun4 suggests a mechanism for its role in chlorophyll biosynthesis.
Davison PA, Schubert HL, Reid JD, Iorg CD, Heroux A, Hill CP, Hunter CN. Davison PA, et al. Biochemistry. 2005 May 31;44(21):7603-12. doi: 10.1021/bi050240x. Biochemistry. 2005. PMID: 15909975 - GUN4-porphyrin complexes bind the ChlH/GUN5 subunit of Mg-Chelatase and promote chlorophyll biosynthesis in Arabidopsis.
Adhikari ND, Froehlich JE, Strand DD, Buck SM, Kramer DM, Larkin RM. Adhikari ND, et al. Plant Cell. 2011 Apr;23(4):1449-67. doi: 10.1105/tpc.110.082503. Epub 2011 Apr 5. Plant Cell. 2011. PMID: 21467578 Free PMC article. - C-terminal residues of oryza sativa GUN4 are required for the activation of the ChlH subunit of magnesium chelatase in chlorophyll synthesis.
Zhou S, Sawicki A, Willows RD, Luo M. Zhou S, et al. FEBS Lett. 2012 Feb 3;586(3):205-10. doi: 10.1016/j.febslet.2011.12.026. Epub 2012 Jan 2. FEBS Lett. 2012. PMID: 22226678 - Pathways of intracellular communication: tetrapyrroles and plastid-to-nucleus signaling.
Rodermel S, Park S. Rodermel S, et al. Bioessays. 2003 Jul;25(7):631-6. doi: 10.1002/bies.10308. Bioessays. 2003. PMID: 12815718 Review. - Retrograde signaling and plant stress: plastid signals initiate cellular stress responses.
Fernández AP, Strand A. Fernández AP, et al. Curr Opin Plant Biol. 2008 Oct;11(5):509-13. doi: 10.1016/j.pbi.2008.06.002. Epub 2008 Jul 17. Curr Opin Plant Biol. 2008. PMID: 18639482 Review.
Cited by
- A missense mutation in the barley Xan-h gene encoding the Mg-chelatase subunit I leads to a viable pale green line with reduced daily transpiration rate.
Persello A, Tadini L, Rotasperti L, Ballabio F, Tagliani A, Torricella V, Jahns P, Dalal A, Moshelion M, Camilloni C, Rosignoli S, Hansson M, Cattivelli L, Horner DS, Rossini L, Tondelli A, Salvi S, Pesaresi P. Persello A, et al. Plant Cell Rep. 2024 Sep 29;43(10):246. doi: 10.1007/s00299-024-03328-2. Plant Cell Rep. 2024. PMID: 39343835 Free PMC article. - Proteomic profiling of Arabidopsis nuclei reveals distinct protein accumulation kinetics upon heat stress.
Muñoz-Díaz E, Fuenzalida-Valdivia I, Darrière T, de Bures A, Blanco-Herrera F, Rompais M, Carapito C, Sáez-Vásquez J. Muñoz-Díaz E, et al. Sci Rep. 2024 Aug 14;14(1):18914. doi: 10.1038/s41598-024-65558-4. Sci Rep. 2024. PMID: 39143125 Free PMC article. - Mitochondrial ATP Synthase _beta_-Subunit Affects Plastid Retrograde Signaling in Arabidopsis.
Liu H, Liu Z, Qin A, Zhou Y, Sun S, Liu Y, Hu M, Yang J, Sun X. Liu H, et al. Int J Mol Sci. 2024 Jul 17;25(14):7829. doi: 10.3390/ijms25147829. Int J Mol Sci. 2024. PMID: 39063070 Free PMC article. - Overexpression of Liriodendron Hybrid LhGLK1 in Arabidopsis Leads to Excessive Chlorophyll Synthesis and Improved Growth.
Qu H, Liang S, Hu L, Yu L, Liang P, Hao Z, Peng Y, Yang J, Shi J, Chen J. Qu H, et al. Int J Mol Sci. 2024 Jun 26;25(13):6968. doi: 10.3390/ijms25136968. Int J Mol Sci. 2024. PMID: 39000074 Free PMC article. - Transcriptomic analysis of hub genes regulating albinism in light- and temperature-sensitive albino tea cultivars 'Zhonghuang 1' and 'Zhonghuang 2'.
Wang L, Di T, Li N, Peng J, Wu Y, He M, Hao X, Huang J, Ding C, Yang Y, Wang X. Wang L, et al. Plant Mol Biol. 2024 Apr 17;114(3):44. doi: 10.1007/s11103-024-01430-3. Plant Mol Biol. 2024. PMID: 38630172
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases