Regulation of muscular contraction. Distribution of actin control and myosin control in the animal kingdom - PubMed (original) (raw)

Regulation of muscular contraction. Distribution of actin control and myosin control in the animal kingdom

W Lehman et al. J Gen Physiol. 1975 Jul.

Abstract

The control systems regulating muscle contraction in approximately 100 organisms have been categorized. Both myosin control and actin control operate simultaneously in the majority of invertebrates tested. These include insects, chelicerates, most crustaceans, annelids, priapulids, nematodes, and some sipunculids. Single myosin control is present in the muscles of molluscs, brachiopods, echinoderms, echiuroids, and nemertine worms. Single actin control was found in the fast muscles of decapods, in mysidacea, in a single sipunculid species, and in vertebrate striated muscles. Classification is based on functional tests that include measurements of the calcium dependence of the actomyosin ATPase activity in the presence and the absence of purified rabbit actin and myosin. In addition, isolated thin filaments and myosins were also analyzed. Molluscs lack actin control since troponin is not present in sufficient quantities. Even though the functional tests indicate the complete lack of myosin control in vertebrate striated muscle, it is difficult to exclude unambiguously the in vivo existence of this regulation. Both control systems have been found in animals from phyla which evolved early. We cannot ascribe any simple correlation between ATPase activity, muscle structure, and regulatory mechanisms.

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References

    1. Biochim Biophys Acta. 1970 Dec 8;223(2):453-6 - PubMed
    1. J Mol Biol. 1971 Mar 14;56(2):239-58 - PubMed
    1. J Mol Biol. 1973 Feb 25;74(2):179-203 - PubMed
    1. FEBS Lett. 1974 Jun 1;42(2):173-8 - PubMed
    1. Biochem Biophys Res Commun. 1974 Sep 23;60(2):656-64 - PubMed

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