Evolutionary aspects of protein structure and folding - PubMed (original) (raw)

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Evolutionary aspects of protein structure and folding

Edward N Trifonov et al. Curr Opin Struct Biol. 2003 Feb.

Abstract

The traditional reconstruction of molecular events of the past based on sequence conservation becomes very vague beyond one to two billion years ago. There are certain molecular features, however, such as polymer flexibility and loop closure, that are conserved merely because of their physical nature. This allows one to penetrate the earliest stages of protein evolution.

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